node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akap9 | Pcnt | ENSRNOP00000073290 | ENSRNOP00000039329 | A-kinase-anchoring protein 9. | Pericentrin. | 0.430 |
Akap9 | Pde4d | ENSRNOP00000073290 | ENSRNOP00000015138 | A-kinase-anchoring protein 9. | cAMP-specific 3',5'-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. | 0.547 |
Akap9 | Pde4dip | ENSRNOP00000073290 | ENSRNOP00000072921 | A-kinase-anchoring protein 9. | Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes. May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation an [...] | 0.508 |
Akap9 | Synm | ENSRNOP00000073290 | ENSRNOP00000068384 | A-kinase-anchoring protein 9. | RCG24674, isoform CRA_e; Belongs to the intermediate filament family. | 0.400 |
Akap9 | Tubgcp2 | ENSRNOP00000073290 | ENSRNOP00000024573 | A-kinase-anchoring protein 9. | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. | 0.461 |
Fam89b | Pde4dip | ENSRNOP00000016987 | ENSRNOP00000072921 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes. May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation an [...] | 0.571 |
Fam89b | Slc66a2 | ENSRNOP00000016987 | ENSRNOP00000074262 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Solute carrier family 66 member 2. | 0.761 |
Mzt1 | Nedd1 | ENSRNOP00000030357 | ENSRNOP00000005463 | Mitotic spindle organizing protein 1. | NEDD1 gamma-tubulin ring complex targeting factor. | 0.955 |
Mzt1 | Pcnt | ENSRNOP00000030357 | ENSRNOP00000039329 | Mitotic spindle organizing protein 1. | Pericentrin. | 0.450 |
Mzt1 | Pde4dip | ENSRNOP00000030357 | ENSRNOP00000072921 | Mitotic spindle organizing protein 1. | Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes. May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation an [...] | 0.549 |
Mzt1 | Tubgcp2 | ENSRNOP00000030357 | ENSRNOP00000024573 | Mitotic spindle organizing protein 1. | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. | 0.979 |
Nedd1 | Mzt1 | ENSRNOP00000005463 | ENSRNOP00000030357 | NEDD1 gamma-tubulin ring complex targeting factor. | Mitotic spindle organizing protein 1. | 0.955 |
Nedd1 | Pcnt | ENSRNOP00000005463 | ENSRNOP00000039329 | NEDD1 gamma-tubulin ring complex targeting factor. | Pericentrin. | 0.806 |
Nedd1 | Pde4dip | ENSRNOP00000005463 | ENSRNOP00000072921 | NEDD1 gamma-tubulin ring complex targeting factor. | Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes. May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation an [...] | 0.514 |
Nedd1 | Tubgcp2 | ENSRNOP00000005463 | ENSRNOP00000024573 | NEDD1 gamma-tubulin ring complex targeting factor. | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. | 0.752 |
Pcnt | Akap9 | ENSRNOP00000039329 | ENSRNOP00000073290 | Pericentrin. | A-kinase-anchoring protein 9. | 0.430 |
Pcnt | Mzt1 | ENSRNOP00000039329 | ENSRNOP00000030357 | Pericentrin. | Mitotic spindle organizing protein 1. | 0.450 |
Pcnt | Nedd1 | ENSRNOP00000039329 | ENSRNOP00000005463 | Pericentrin. | NEDD1 gamma-tubulin ring complex targeting factor. | 0.806 |
Pcnt | Pde4dip | ENSRNOP00000039329 | ENSRNOP00000072921 | Pericentrin. | Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes. May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation an [...] | 0.634 |
Pcnt | Tubgcp2 | ENSRNOP00000039329 | ENSRNOP00000024573 | Pericentrin. | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. | 0.579 |