node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cma1 | Cpa3 | ENSRNOP00000061330 | ENSRNOP00000014970 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Mast cell carboxypeptidase A. | 0.977 |
Cma1 | Elane | ENSRNOP00000061330 | ENSRNOP00000014981 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Elastase 2, neutrophil (Predicted); Belongs to the peptidase S1 family. | 0.530 |
Cma1 | Fcer1a | ENSRNOP00000061330 | ENSRNOP00000069343 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.743 |
Cma1 | Hdc | ENSRNOP00000061330 | ENSRNOP00000041885 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.527 |
Cma1 | Mcpt1l1 | ENSRNOP00000061330 | ENSRNOP00000069831 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Mast cell protease 1; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits. | 0.988 |
Cma1 | Mrgprx2 | ENSRNOP00000061330 | ENSRNOP00000046598 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | MAS-related GPR family member X2; Belongs to the G-protein coupled receptor 1 family. | 0.568 |
Cma1 | Srgn | ENSRNOP00000061330 | ENSRNOP00000000443 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...] | 0.667 |
Cma1 | Tpsab1 | ENSRNOP00000061330 | ENSRNOP00000025095 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily. | 0.638 |
Cma1 | Tpsb2 | ENSRNOP00000061330 | ENSRNOP00000025220 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.946 |
Cpa3 | Cma1 | ENSRNOP00000014970 | ENSRNOP00000061330 | Mast cell carboxypeptidase A. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.977 |
Cpa3 | Fcer1a | ENSRNOP00000014970 | ENSRNOP00000069343 | Mast cell carboxypeptidase A. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.835 |
Cpa3 | Hdc | ENSRNOP00000014970 | ENSRNOP00000041885 | Mast cell carboxypeptidase A. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.753 |
Cpa3 | Mcpt1l1 | ENSRNOP00000014970 | ENSRNOP00000069831 | Mast cell carboxypeptidase A. | Mast cell protease 1; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits. | 0.944 |
Cpa3 | Mrgprx2 | ENSRNOP00000014970 | ENSRNOP00000046598 | Mast cell carboxypeptidase A. | MAS-related GPR family member X2; Belongs to the G-protein coupled receptor 1 family. | 0.683 |
Cpa3 | Ndst2-2 | ENSRNOP00000014970 | ENSRNOP00000031692 | Mast cell carboxypeptidase A. | N-deacetylase and N-sulfotransferase 2. | 0.652 |
Cpa3 | Srgn | ENSRNOP00000014970 | ENSRNOP00000000443 | Mast cell carboxypeptidase A. | Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...] | 0.730 |
Cpa3 | Tpsab1 | ENSRNOP00000014970 | ENSRNOP00000025095 | Mast cell carboxypeptidase A. | Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily. | 0.834 |
Cpa3 | Tpsb2 | ENSRNOP00000014970 | ENSRNOP00000025220 | Mast cell carboxypeptidase A. | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.895 |
Elane | Cma1 | ENSRNOP00000014981 | ENSRNOP00000061330 | Elastase 2, neutrophil (Predicted); Belongs to the peptidase S1 family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.530 |
Elane | Tpsb2 | ENSRNOP00000014981 | ENSRNOP00000025220 | Elastase 2, neutrophil (Predicted); Belongs to the peptidase S1 family. | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.490 |