node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adcyap1r1 | Vip | ENSRNOP00000016175 | ENSRNOP00000075997 | Pituitary adenylate cyclase-activating polypeptide type I receptor; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.956 |
Adcyap1r1 | Vipr2 | ENSRNOP00000016175 | ENSRNOP00000005876 | Pituitary adenylate cyclase-activating polypeptide type I receptor; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. | Vasoactive intestinal polypeptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. | 0.485 |
Drd1 | LOC100912228 | ENSRNOP00000034820 | ENSRNOP00000066713 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | Neuropeptide Y. | 0.461 |
Drd1 | Npy | ENSRNOP00000034820 | ENSRNOP00000013146 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.467 |
Drd1 | Tac1 | ENSRNOP00000034820 | ENSRNOP00000009888 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | C-terminal-flanking peptide; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Belongs to the tachykinin family. | 0.678 |
Drd1 | Vip | ENSRNOP00000034820 | ENSRNOP00000075997 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.917 |
Gipr | Glp1r | ENSRNOP00000021456 | ENSRNOP00000001527 | Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | 0.507 |
Gipr | Vip | ENSRNOP00000021456 | ENSRNOP00000075997 | Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.928 |
Glp1r | Gipr | ENSRNOP00000001527 | ENSRNOP00000021456 | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.507 |
Glp1r | LOC100912228 | ENSRNOP00000001527 | ENSRNOP00000066713 | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | Neuropeptide Y. | 0.675 |
Glp1r | Npy | ENSRNOP00000001527 | ENSRNOP00000013146 | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.675 |
Glp1r | Vip | ENSRNOP00000001527 | ENSRNOP00000075997 | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.933 |
Htr4 | Vip | ENSRNOP00000025892 | ENSRNOP00000075997 | 5-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.916 |
LOC100912228 | Drd1 | ENSRNOP00000066713 | ENSRNOP00000034820 | Neuropeptide Y. | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | 0.461 |
LOC100912228 | Glp1r | ENSRNOP00000066713 | ENSRNOP00000001527 | Neuropeptide Y. | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). | 0.675 |
LOC100912228 | Tac1 | ENSRNOP00000066713 | ENSRNOP00000009888 | Neuropeptide Y. | C-terminal-flanking peptide; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Belongs to the tachykinin family. | 0.950 |
LOC100912228 | Vip | ENSRNOP00000066713 | ENSRNOP00000075997 | Neuropeptide Y. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.942 |
LOC100912228 | Vipr2 | ENSRNOP00000066713 | ENSRNOP00000005876 | Neuropeptide Y. | Vasoactive intestinal polypeptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. | 0.485 |
Mc2r | Vip | ENSRNOP00000022347 | ENSRNOP00000075997 | Melanocortin 2 receptor. | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. | 0.918 |
Npy | Drd1 | ENSRNOP00000013146 | ENSRNOP00000034820 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | 0.467 |