STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ca5aCarbonic anhydrase 5A, mitochondrial; Reversible hydration of carbon dioxide. Low activity; Belongs to the alpha-carbonic anhydrase family. (304 aa)    
Predicted Functional Partners:
Ca5b
Carbonic anhydrase 5B, mitochondrial; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family.
  
  
0.718
Rpf2
Ribosome production factor 2 homolog.
   
 
 0.584
Lrrc49
Leucine-rich repeat-containing 49.
      
 0.528
Nags
N-acetylglutamate synthase (Predicted), isoform CRA_a.
   
  
 0.524
Slc4a4
Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Belongs to the anion exchanger (TC 2.A.31) family.
   
 
 0.493
Rrs1
Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
   
 
 0.490
Grwd1
Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.
   
  
 0.484
Serpinb6b
Serine (or cysteine) peptidase inhibitor, clade B, member 6b; Belongs to the serpin family.
   
 
 0.464
Serpinb8
Serine (Or cysteine) peptdiase inhibitor, clade B, member 8 (Predicted); Belongs to the serpin family.
   
 
 0.454
Serpinb7
Serine (Or cysteine) proteinase inhibitor, clade B, member 7; Belongs to the serpin family.
   
 
 0.454
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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