node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Egfr | LOC100910021 | ENSRNOP00000006087 | ENSRNOP00000035786 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | 0.411 |
Egfr | LOC685590 | ENSRNOP00000006087 | ENSRNOP00000073549 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.971 |
Egfr | Pik3ca | ENSRNOP00000006087 | ENSRNOP00000072496 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (By similarity). Participates in cel [...] | 0.993 |
Egfr | Pik3cb | ENSRNOP00000006087 | ENSRNOP00000022179 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation [...] | 0.962 |
Egfr | Pik3cd | ENSRNOP00000006087 | ENSRNOP00000061674 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.935 |
Egfr | Pik3cg | ENSRNOP00000006087 | ENSRNOP00000012487 | Receptor protein-tyrosine kinase. | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. | 0.621 |
Egfr | Pik3r1 | ENSRNOP00000006087 | ENSRNOP00000025687 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.989 |
Egfr | Pik3r2 | ENSRNOP00000006087 | ENSRNOP00000026210 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.972 |
Egfr | Pik3r3 | ENSRNOP00000006087 | ENSRNOP00000000157 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.975 |
Egfr | Pten | ENSRNOP00000006087 | ENSRNOP00000028143 | Receptor protein-tyrosine kinase. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. | 0.874 |
LOC100910021 | Egfr | ENSRNOP00000035786 | ENSRNOP00000006087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Receptor protein-tyrosine kinase. | 0.411 |
LOC100910021 | LOC685590 | ENSRNOP00000035786 | ENSRNOP00000073549 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.577 |
LOC100910021 | Pik3ca | ENSRNOP00000035786 | ENSRNOP00000072496 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (By similarity). Participates in cel [...] | 0.577 |
LOC100910021 | Pik3cd | ENSRNOP00000035786 | ENSRNOP00000061674 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.747 |
LOC100910021 | Pik3cg | ENSRNOP00000035786 | ENSRNOP00000012487 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. | 0.737 |
LOC100910021 | Pik3r1 | ENSRNOP00000035786 | ENSRNOP00000025687 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.933 |
LOC100910021 | Pik3r2 | ENSRNOP00000035786 | ENSRNOP00000026210 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.992 |
LOC100910021 | Pik3r3 | ENSRNOP00000035786 | ENSRNOP00000000157 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.786 |
LOC100910021 | Pten | ENSRNOP00000035786 | ENSRNOP00000028143 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. | 0.442 |
LOC685590 | Egfr | ENSRNOP00000073549 | ENSRNOP00000006087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Receptor protein-tyrosine kinase. | 0.971 |