Pc protein (Rattus norvegicus) - STRING interaction network

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Pc

Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. (1277 aa)

Predicted Functional Partners:

Cs

0.985

Pck1

0.980

Me1

0.975

Acly

0.973

Mdh2

0.972

Pck2

0.970

Pklr

0.969

Ldha

0.965

Mdh1

0.963

LOC100362738

0.963

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acly	Cs	ENSRNOP00000023447	ENSRNOP00000034921	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase, mitochondrial.	0.994
Acly	LOC100362738	ENSRNOP00000023447	ENSRNOP00000067507	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.704
Acly	Ldha	ENSRNOP00000023447	ENSRNOP00000017468	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	L-lactate dehydrogenase A chain.	0.736
Acly	Mdh1	ENSRNOP00000023447	ENSRNOP00000011429	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase, cytoplasmic.	0.960
Acly	Mdh2	ENSRNOP00000023447	ENSRNOP00000001958	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase, mitochondrial; Belongs to the LDH/MDH superfamily. MDH type 1 family.	0.958
Acly	Me1	ENSRNOP00000023447	ENSRNOP00000071968	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	NADP-dependent malic enzyme; Belongs to the malic enzymes family.	0.790
Acly	Pc	ENSRNOP00000023447	ENSRNOP00000068757	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.	0.973
Acly	Pck1	ENSRNOP00000023447	ENSRNOP00000030913	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate.	0.949
Acly	Pck2	ENSRNOP00000023447	ENSRNOP00000025260	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Phosphoenolpyruvate carboxykinase 2 (mitochondrial).	0.929
Acly	Pklr	ENSRNOP00000023447	ENSRNOP00000027700	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate kinase PKLR; Plays a key role in glycolysis.	0.615
Cs	Acly	ENSRNOP00000034921	ENSRNOP00000023447	Citrate synthase, mitochondrial.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.994
Cs	LOC100362738	ENSRNOP00000034921	ENSRNOP00000067507	Citrate synthase, mitochondrial.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.710
Cs	Ldha	ENSRNOP00000034921	ENSRNOP00000017468	Citrate synthase, mitochondrial.	L-lactate dehydrogenase A chain.	0.903
Cs	Mdh1	ENSRNOP00000034921	ENSRNOP00000011429	Citrate synthase, mitochondrial.	Malate dehydrogenase, cytoplasmic.	0.983
Cs	Mdh2	ENSRNOP00000034921	ENSRNOP00000001958	Citrate synthase, mitochondrial.	Malate dehydrogenase, mitochondrial; Belongs to the LDH/MDH superfamily. MDH type 1 family.	0.998
Cs	Me1	ENSRNOP00000034921	ENSRNOP00000071968	Citrate synthase, mitochondrial.	NADP-dependent malic enzyme; Belongs to the malic enzymes family.	0.944
Cs	Pc	ENSRNOP00000034921	ENSRNOP00000068757	Citrate synthase, mitochondrial.	Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.	0.985
Cs	Pck1	ENSRNOP00000034921	ENSRNOP00000030913	Citrate synthase, mitochondrial.	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate.	0.934
Cs	Pck2	ENSRNOP00000034921	ENSRNOP00000025260	Citrate synthase, mitochondrial.	Phosphoenolpyruvate carboxykinase 2 (mitochondrial).	0.926
Cs	Pklr	ENSRNOP00000034921	ENSRNOP00000027700	Citrate synthase, mitochondrial.	Pyruvate kinase PKLR; Plays a key role in glycolysis.	0.455

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