node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef37 | Fcho1 | ENSRNOP00000069658 | ENSRNOP00000049715 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | FCH and mu domain-containing endocytic adaptor 1. | 0.437 |
Arhgef37 | Fchsd1 | ENSRNOP00000069658 | ENSRNOP00000026381 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | 0.710 |
Arhgef37 | Fnbp1 | ENSRNOP00000069658 | ENSRNOP00000049838 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By s [...] | 0.528 |
Dnmbp | Fchsd1 | ENSRNOP00000064242 | ENSRNOP00000026381 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | 0.648 |
Dnmbp | Fnbp1 | ENSRNOP00000064242 | ENSRNOP00000049838 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By s [...] | 0.433 |
Dnmbp | Snx9 | ENSRNOP00000064242 | ENSRNOP00000066186 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. | Sorting nexin. | 0.457 |
Dnmbp | Wasl | ENSRNOP00000064242 | ENSRNOP00000009261 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.770 |
Fam193b | Fchsd1 | ENSRNOP00000017350 | ENSRNOP00000026381 | Family with sequence similarity 193, member B. | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | 0.745 |
Fam193b | Ik | ENSRNOP00000017350 | ENSRNOP00000044213 | Family with sequence similarity 193, member B. | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). Belongs to the WD repeat WDR55 family. | 0.902 |
Fcho1 | Arhgef37 | ENSRNOP00000049715 | ENSRNOP00000069658 | FCH and mu domain-containing endocytic adaptor 1. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.437 |
Fcho1 | Fchsd1 | ENSRNOP00000049715 | ENSRNOP00000026381 | FCH and mu domain-containing endocytic adaptor 1. | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | 0.679 |
Fcho1 | Fnbp1 | ENSRNOP00000049715 | ENSRNOP00000049838 | FCH and mu domain-containing endocytic adaptor 1. | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By s [...] | 0.735 |
Fcho1 | Itsn1 | ENSRNOP00000049715 | ENSRNOP00000044773 | FCH and mu domain-containing endocytic adaptor 1. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.974 |
Fcho1 | Itsn2 | ENSRNOP00000049715 | ENSRNOP00000065329 | FCH and mu domain-containing endocytic adaptor 1. | Intersectin 2. | 0.936 |
Fcho1 | Snx9 | ENSRNOP00000049715 | ENSRNOP00000066186 | FCH and mu domain-containing endocytic adaptor 1. | Sorting nexin. | 0.620 |
Fcho1 | Wasl | ENSRNOP00000049715 | ENSRNOP00000009261 | FCH and mu domain-containing endocytic adaptor 1. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.625 |
Fchsd1 | Arhgef37 | ENSRNOP00000026381 | ENSRNOP00000069658 | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.710 |
Fchsd1 | Dnmbp | ENSRNOP00000026381 | ENSRNOP00000064242 | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. | 0.648 |
Fchsd1 | Fam193b | ENSRNOP00000026381 | ENSRNOP00000017350 | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | Family with sequence similarity 193, member B. | 0.745 |
Fchsd1 | Fcho1 | ENSRNOP00000026381 | ENSRNOP00000049715 | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. | FCH and mu domain-containing endocytic adaptor 1. | 0.679 |