node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actb | Actr10 | ENSRNOP00000072672 | ENSRNOP00000010300 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | 0.983 |
Actb | Actr1a | ENSRNOP00000072672 | ENSRNOP00000026792 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). | 0.983 |
Actb | Dctn1 | ENSRNOP00000072672 | ENSRNOP00000059076 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.718 |
Actb | Dctn2 | ENSRNOP00000072672 | ENSRNOP00000069048 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | 0.855 |
Actb | Dctn4 | ENSRNOP00000072672 | ENSRNOP00000026394 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.972 |
Actb | Dctn5 | ENSRNOP00000072672 | ENSRNOP00000024367 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | RCG39275, isoform CRA_b. | 0.818 |
Actb | Dctn6 | ENSRNOP00000072672 | ENSRNOP00000017756 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Dynactin 6 (Predicted), isoform CRA_b. | 0.815 |
Actb | Dync1h1 | ENSRNOP00000072672 | ENSRNOP00000066312 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression; Belongs to the dynein heavy chain family. | 0.439 |
Actr10 | Actb | ENSRNOP00000010300 | ENSRNOP00000072672 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.983 |
Actr10 | Actr1a | ENSRNOP00000010300 | ENSRNOP00000026792 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). | 0.998 |
Actr10 | Actr1b | ENSRNOP00000010300 | ENSRNOP00000022779 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | ARP1 actin-related protein 1 homolog B (Yeast). | 0.983 |
Actr10 | Dctn1 | ENSRNOP00000010300 | ENSRNOP00000059076 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.996 |
Actr10 | Dctn2 | ENSRNOP00000010300 | ENSRNOP00000069048 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | 0.998 |
Actr10 | Dctn3 | ENSRNOP00000010300 | ENSRNOP00000019561 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | RCG55152, isoform CRA_a. | 0.988 |
Actr10 | Dctn4 | ENSRNOP00000010300 | ENSRNOP00000026394 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.998 |
Actr10 | Dctn5 | ENSRNOP00000010300 | ENSRNOP00000024367 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | RCG39275, isoform CRA_b. | 0.998 |
Actr10 | Dctn6 | ENSRNOP00000010300 | ENSRNOP00000017756 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Dynactin 6 (Predicted), isoform CRA_b. | 0.999 |
Actr10 | Dync1h1 | ENSRNOP00000010300 | ENSRNOP00000066312 | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression; Belongs to the dynein heavy chain family. | 0.809 |
Actr1a | Actb | ENSRNOP00000026792 | ENSRNOP00000072672 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.983 |
Actr1a | Actr10 | ENSRNOP00000026792 | ENSRNOP00000010300 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). | ARP10 actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family. | 0.998 |