node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cel | Cela2a | ENSRNOP00000014572 | ENSRNOP00000018349 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | 0.986 |
Cel | Cela3b | ENSRNOP00000014572 | ENSRNOP00000036674 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Elastase 3B, pancreatic (Predicted), isoform CRA_b; Belongs to the peptidase S1 family. | 0.984 |
Cel | Clps | ENSRNOP00000014572 | ENSRNOP00000073599 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.935 |
Cel | Cpa1 | ENSRNOP00000014572 | ENSRNOP00000014465 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.986 |
Cel | Ctrb1 | ENSRNOP00000014572 | ENSRNOP00000026017 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | 0.987 |
Cel | Pnlip | ENSRNOP00000014572 | ENSRNOP00000024065 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. | 0.997 |
Cel | Pnliprp1 | ENSRNOP00000014572 | ENSRNOP00000024164 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). Belongs to the AB hydrolase superfamily. Lipase family. | 0.989 |
Cel | Prss3 | ENSRNOP00000014572 | ENSRNOP00000018042 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Cationic trypsin-3. | 0.984 |
Cel | Sycn | ENSRNOP00000014572 | ENSRNOP00000026907 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. | 0.638 |
Cel | Zg16 | ENSRNOP00000014572 | ENSRNOP00000022758 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. | 0.543 |
Cela2a | Cel | ENSRNOP00000018349 | ENSRNOP00000014572 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | 0.986 |
Cela2a | Cela3b | ENSRNOP00000018349 | ENSRNOP00000036674 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Elastase 3B, pancreatic (Predicted), isoform CRA_b; Belongs to the peptidase S1 family. | 0.998 |
Cela2a | Clps | ENSRNOP00000018349 | ENSRNOP00000073599 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.902 |
Cela2a | Cpa1 | ENSRNOP00000018349 | ENSRNOP00000014465 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.995 |
Cela2a | Ctrb1 | ENSRNOP00000018349 | ENSRNOP00000026017 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | 0.974 |
Cela2a | Pnlip | ENSRNOP00000018349 | ENSRNOP00000024065 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. | 0.987 |
Cela2a | Pnliprp1 | ENSRNOP00000018349 | ENSRNOP00000024164 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). Belongs to the AB hydrolase superfamily. Lipase family. | 0.926 |
Cela2a | Prss3 | ENSRNOP00000018349 | ENSRNOP00000018042 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Cationic trypsin-3. | 0.804 |
Cela2a | Sycn | ENSRNOP00000018349 | ENSRNOP00000026907 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. | 0.651 |
Cela2a | Zg16 | ENSRNOP00000018349 | ENSRNOP00000022758 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. | 0.521 |