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Ppp4c protein (Rattus norvegicus) - STRING interaction network
"Ppp4c" - Serine/threonine-protein phosphatase 4 catalytic subunit in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Ppp4cSerine/threonine-protein phosphatase 4 catalytic subunit ; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosph [...] (307 aa)    
Predicted Functional Partners:
Igbp1
Immunoglobulin-binding protein 1 ; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits (By similarity) (340 aa)
     
 
  0.920
Igbp1b
Immunoglobulin-binding protein 1b (344 aa)
     
 
  0.920
Ppp2r1a
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (589 aa)
     
  0.875
Ppp2r1b
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform ; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (601 aa)
     
  0.870
Phlpp2
PH domain leucine-rich repeat-containing protein phosphatase 2 (1358 aa)
     
 
  0.833
Phlpp1
PH domain leucine-rich repeat protein phosphatase 1 ; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT2 and AKT3, ’Ser-660’ of PRKCB and ’Ser-657’ of PRKCA (PubMed-20819118). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons while isoform 1 may promote Akt and PKC activation and inhibit ERK signaling (PubMed-20819118). Akt regulates the balance between cell survival and [...] (1696 aa)
     
 
  0.833
Ppp4r1
Serine/threonine-protein phosphatase 4 regulatory subunit 1 ; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3 (By similarity) (934 aa)
     
 
  0.825
Crtc2
CREB-regulated transcription coactivator 2 ; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mi [...] (691 aa)
     
  0.815
Ppp2r2b
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform ; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (240 aa)
     
  0.795
Lrrk1
Leucine-rich repeat serine/threonine-protein kinase 1 (2013 aa)
     
 
  0.795
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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