STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lypd3Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression. (352 aa)    
Predicted Functional Partners:
Agr2
Anterior gradient 2 (Xenopus laevis) (Predicted), isoform CRA_a.
   
 
 0.741
Agr3
Anterior gradient 3, protein disulphide isomerase family member.
    
 
 0.661
Zfp575
RCG54405, isoform CRA_a.
      
 0.627
Plbd2
Putative phospholipase B-like 2; Putative phospholipase; Belongs to the phospholipase B-like family.
   
  
 0.606
Phldb3
Pleckstrin homology-like domain, family B, member 3.
      
 0.605
Krt5
Keratin, type II cytoskeletal 5.
   
  
 0.593
Pinlyp
Phospholipase A2 inhibitor and LY6/PLAUR domain-containing.
   
  
 0.582
Tex101
Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation.
   
  
 0.540
Mmp14
Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...]
   
  
 0.532
Gpld1
Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
   
 
 0.518
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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