| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cd27 | Cd40lg | ENSRNOP00000029803 | ENSRNOP00000001162 | Similar to CD27 antigen-mouse, isoform CRA_b. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.864 |
| Cd27 | Cd70 | ENSRNOP00000029803 | ENSRNOP00000064850 | Similar to CD27 antigen-mouse, isoform CRA_b. | Cd70 molecule; Belongs to the tumor necrosis factor family. | 0.999 |
| Cd27 | Cd80 | ENSRNOP00000029803 | ENSRNOP00000002089 | Similar to CD27 antigen-mouse, isoform CRA_b. | CD80 antigen, isoform CRA_a. | 0.938 |
| Cd27 | Cd86 | ENSRNOP00000029803 | ENSRNOP00000003129 | Similar to CD27 antigen-mouse, isoform CRA_b. | Cd86 antigen, isoform CRA_c. | 0.940 |
| Cd27 | Icos | ENSRNOP00000029803 | ENSRNOP00000064455 | Similar to CD27 antigen-mouse, isoform CRA_b. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.787 |
| Cd27 | Icoslg | ENSRNOP00000029803 | ENSRNOP00000031382 | Similar to CD27 antigen-mouse, isoform CRA_b. | Inducible T-cell co-stimulator ligand. | 0.914 |
| Cd27 | Tnfrsf4 | ENSRNOP00000029803 | ENSRNOP00000027251 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). | 0.889 |
| Cd27 | Tnfrsf9 | ENSRNOP00000029803 | ENSRNOP00000052371 | Similar to CD27 antigen-mouse, isoform CRA_b. | Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a. | 0.884 |
| Cd27 | Tnfsf4 | ENSRNOP00000029803 | ENSRNOP00000003969 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family. | 0.952 |
| Cd27 | Tnfsf9 | ENSRNOP00000029803 | ENSRNOP00000066298 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor (Ligand) superfamily, member 9; Belongs to the tumor necrosis factor family. | 0.846 |
| Cd40lg | Cd27 | ENSRNOP00000001162 | ENSRNOP00000029803 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Similar to CD27 antigen-mouse, isoform CRA_b. | 0.864 |
| Cd40lg | Cd70 | ENSRNOP00000001162 | ENSRNOP00000064850 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Cd70 molecule; Belongs to the tumor necrosis factor family. | 0.937 |
| Cd40lg | Cd80 | ENSRNOP00000001162 | ENSRNOP00000002089 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | CD80 antigen, isoform CRA_a. | 0.996 |
| Cd40lg | Cd86 | ENSRNOP00000001162 | ENSRNOP00000003129 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Cd86 antigen, isoform CRA_c. | 0.995 |
| Cd40lg | Icos | ENSRNOP00000001162 | ENSRNOP00000064455 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.996 |
| Cd40lg | Icoslg | ENSRNOP00000001162 | ENSRNOP00000031382 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Inducible T-cell co-stimulator ligand. | 0.946 |
| Cd40lg | Tnfrsf4 | ENSRNOP00000001162 | ENSRNOP00000027251 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). | 0.917 |
| Cd40lg | Tnfrsf9 | ENSRNOP00000001162 | ENSRNOP00000052371 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a. | 0.838 |
| Cd40lg | Tnfsf4 | ENSRNOP00000001162 | ENSRNOP00000003969 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family. | 0.924 |
| Cd40lg | Tnfsf9 | ENSRNOP00000001162 | ENSRNOP00000066298 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor (Ligand) superfamily, member 9; Belongs to the tumor necrosis factor family. | 0.774 |