node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dbh | Ddc | ENSRNOP00000057915 | ENSRNOP00000005851 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | 0.984 |
Dbh | Slc18a2 | ENSRNOP00000057915 | ENSRNOP00000011983 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.731 |
Dbh | Snca | ENSRNOP00000057915 | ENSRNOP00000030609 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.401 |
Dbh | Spr | ENSRNOP00000057915 | ENSRNOP00000020749 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. | 0.697 |
Dbh | Th | ENSRNOP00000057915 | ENSRNOP00000027682 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.946 |
Dbh | Tyr | ENSRNOP00000057915 | ENSRNOP00000021971 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Tyrosinase (Albino coat color) (Mapped), isoform CRA_a. | 0.516 |
Ddc | Dbh | ENSRNOP00000005851 | ENSRNOP00000057915 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.984 |
Ddc | Got2 | ENSRNOP00000005851 | ENSRNOP00000015956 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.933 |
Ddc | Qdpr | ENSRNOP00000005851 | ENSRNOP00000004385 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.453 |
Ddc | Slc18a2 | ENSRNOP00000005851 | ENSRNOP00000011983 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.967 |
Ddc | Snca | ENSRNOP00000005851 | ENSRNOP00000030609 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.729 |
Ddc | Spr | ENSRNOP00000005851 | ENSRNOP00000020749 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. | 0.531 |
Ddc | Th | ENSRNOP00000005851 | ENSRNOP00000027682 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.994 |
Ddc | Tyr | ENSRNOP00000005851 | ENSRNOP00000021971 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Tyrosinase (Albino coat color) (Mapped), isoform CRA_a. | 0.941 |
Got2 | Ddc | ENSRNOP00000015956 | ENSRNOP00000005851 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | 0.933 |
Got2 | Pcbd1 | ENSRNOP00000015956 | ENSRNOP00000000687 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity; Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.588 |
Got2 | Pcbd2 | ENSRNOP00000015956 | ENSRNOP00000067457 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Pterin-4 alpha-carbinolamine dehydratase 2. | 0.581 |
Got2 | Th | ENSRNOP00000015956 | ENSRNOP00000027682 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.945 |
Got2 | Tyr | ENSRNOP00000015956 | ENSRNOP00000021971 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Tyrosinase (Albino coat color) (Mapped), isoform CRA_a. | 0.913 |
Pcbd1 | Got2 | ENSRNOP00000000687 | ENSRNOP00000015956 | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity; Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.588 |