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Pklr protein (Rattus norvegicus) - STRING interaction network
"Pklr" - Pyruvate kinase PKLR in Rattus norvegicus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PklrPyruvate kinase PKLR; Plays a key role in glycolysis (574 aa)    
Predicted Functional Partners:
Eno4
Similar to enolase (46.6 kD) (2J223) (Predicted); Enolase family member 4 (602 aa)
   
  0.976
Pc
Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1178 aa)
     
  0.976
Ldhc
L-lactate dehydrogenase C chain; Possible role in sperm motility (332 aa)
   
  0.972
Pck1
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (622 aa)
     
 
  0.970
Eno1
Alpha-enolase; Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family (434 aa)
   
  0.970
Eno3
Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family (434 aa)
   
  0.968
Ldha
Lactate dehydrogenase A (332 aa)
   
  0.967
Ldhb
Lactate dehydrogenase B; Belongs to the LDH/MDH superfamily. LDH family (334 aa)
   
  0.967
Gpi
Glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity) (558 aa)
   
 
  0.966
Eno-2
Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival; Belongs to the enolase family (434 aa)
   
  0.961
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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