| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Actn1 | Actn3 | ENSRNOP00000068851 | ENSRNOP00000026812 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Skeletal muscle-specific alpha-actinin 3. | 0.965 |
| Actn1 | Actn4 | ENSRNOP00000068851 | ENSRNOP00000027773 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] | 0.999 |
| Actn1 | Itga3 | ENSRNOP00000068851 | ENSRNOP00000034608 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.896 |
| Actn1 | Itgb1 | ENSRNOP00000068851 | ENSRNOP00000014785 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.931 |
| Actn1 | Lmo7 | ENSRNOP00000068851 | ENSRNOP00000074706 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | LIM domain 7. | 0.916 |
| Actn1 | Magi1 | ENSRNOP00000068851 | ENSRNOP00000071015 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. | 0.917 |
| Actn1 | Micall2 | ENSRNOP00000068851 | ENSRNOP00000031199 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes [...] | 0.940 |
| Actn1 | Nphs1 | ENSRNOP00000068851 | ENSRNOP00000049922 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion; Belongs to the immunoglobulin superfamily. | 0.516 |
| Actn1 | Vcl | ENSRNOP00000068851 | ENSRNOP00000074748 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. | 0.997 |
| Actn1 | Zyx | ENSRNOP00000068851 | ENSRNOP00000023537 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Zyxin. | 0.975 |
| Actn3 | Actn1 | ENSRNOP00000026812 | ENSRNOP00000068851 | Skeletal muscle-specific alpha-actinin 3. | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | 0.965 |
| Actn3 | Actn4 | ENSRNOP00000026812 | ENSRNOP00000027773 | Skeletal muscle-specific alpha-actinin 3. | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] | 0.954 |
| Actn3 | Itga3 | ENSRNOP00000026812 | ENSRNOP00000034608 | Skeletal muscle-specific alpha-actinin 3. | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.608 |
| Actn3 | Itgb1 | ENSRNOP00000026812 | ENSRNOP00000014785 | Skeletal muscle-specific alpha-actinin 3. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.432 |
| Actn3 | Lmo7 | ENSRNOP00000026812 | ENSRNOP00000074706 | Skeletal muscle-specific alpha-actinin 3. | LIM domain 7. | 0.647 |
| Actn3 | Magi1 | ENSRNOP00000026812 | ENSRNOP00000071015 | Skeletal muscle-specific alpha-actinin 3. | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. | 0.664 |
| Actn3 | Micall2 | ENSRNOP00000026812 | ENSRNOP00000031199 | Skeletal muscle-specific alpha-actinin 3. | MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes [...] | 0.601 |
| Actn3 | Vcl | ENSRNOP00000026812 | ENSRNOP00000074748 | Skeletal muscle-specific alpha-actinin 3. | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. | 0.903 |
| Actn3 | Zyx | ENSRNOP00000026812 | ENSRNOP00000023537 | Skeletal muscle-specific alpha-actinin 3. | Zyxin. | 0.773 |
| Actn4 | Actn1 | ENSRNOP00000027773 | ENSRNOP00000068851 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | 0.999 |
