node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dcn | Eng | ENSRNOP00000006070 | ENSRNOP00000066838 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Endoglin. | 0.474 |
Dcn | Ltbp1 | ENSRNOP00000006070 | ENSRNOP00000040099 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.628 |
Dcn | Ltbp4 | ENSRNOP00000006070 | ENSRNOP00000028322 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Latent-transforming growth factor beta-binding protein 4. | 0.421 |
Dcn | Smad7 | ENSRNOP00000006070 | ENSRNOP00000024831 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...] | 0.490 |
Dcn | Tgfb1 | ENSRNOP00000006070 | ENSRNOP00000028051 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.999 |
Dcn | Tgfbr1 | ENSRNOP00000006070 | ENSRNOP00000009452 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] | 0.466 |
Dcn | Tgfbr2 | ENSRNOP00000006070 | ENSRNOP00000035501 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.480 |
Dcn | Tgfbr3 | ENSRNOP00000006070 | ENSRNOP00000002867 | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. | 0.527 |
Eng | Dcn | ENSRNOP00000066838 | ENSRNOP00000006070 | Endoglin. | Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. | 0.474 |
Eng | Itgav | ENSRNOP00000066838 | ENSRNOP00000069681 | Endoglin. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.668 |
Eng | LOC103690035 | ENSRNOP00000066838 | ENSRNOP00000066202 | Endoglin. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.674 |
Eng | Smad7 | ENSRNOP00000066838 | ENSRNOP00000024831 | Endoglin. | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...] | 0.410 |
Eng | Tgfb1 | ENSRNOP00000066838 | ENSRNOP00000028051 | Endoglin. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.995 |
Eng | Tgfbr1 | ENSRNOP00000066838 | ENSRNOP00000009452 | Endoglin. | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] | 0.846 |
Eng | Tgfbr2 | ENSRNOP00000066838 | ENSRNOP00000035501 | Endoglin. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.916 |
Itgav | Eng | ENSRNOP00000069681 | ENSRNOP00000066838 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Endoglin. | 0.668 |
Itgav | Ltbp1 | ENSRNOP00000069681 | ENSRNOP00000040099 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.756 |
Itgav | Tgfb1 | ENSRNOP00000069681 | ENSRNOP00000028051 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.983 |
LOC103690035 | Eng | ENSRNOP00000066202 | ENSRNOP00000066838 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Endoglin. | 0.674 |
LOC103690035 | Smad7 | ENSRNOP00000066202 | ENSRNOP00000024831 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...] | 0.966 |