| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Crbn | Cul4a | ENSRNOP00000008873 | ENSRNOP00000026653 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | RGD1563853 protein; Belongs to the cullin family. | 0.999 |
| Crbn | Cul4b | ENSRNOP00000008873 | ENSRNOP00000060639 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.992 |
| Crbn | Dcaf1 | ENSRNOP00000008873 | ENSRNOP00000075456 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | DDB1 and CUL4-associated factor 1. | 0.769 |
| Crbn | Dcaf11 | ENSRNOP00000008873 | ENSRNOP00000074435 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.753 |
| Crbn | Dda1 | ENSRNOP00000008873 | ENSRNOP00000057149 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | DET1 and DDB1-associated 1. | 0.765 |
| Crbn | Ddb1 | ENSRNOP00000008873 | ENSRNOP00000028188 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.999 |
| Crbn | Ddb2 | ENSRNOP00000008873 | ENSRNOP00000018998 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | Damage-specific DNA-binding protein 2. | 0.852 |
| Crbn | Dtl | ENSRNOP00000008873 | ENSRNOP00000005576 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | Denticleless E3 ubiquitin protein ligase homolog. | 0.736 |
| Crbn | Ercc8 | ENSRNOP00000008873 | ENSRNOP00000013598 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.722 |
| Crbn | Rbx1 | ENSRNOP00000008873 | ENSRNOP00000069049 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | Ring-box 1. | 0.994 |
| Cul4a | Crbn | ENSRNOP00000026653 | ENSRNOP00000008873 | RGD1563853 protein; Belongs to the cullin family. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | 0.999 |
| Cul4a | Cul4b | ENSRNOP00000026653 | ENSRNOP00000060639 | RGD1563853 protein; Belongs to the cullin family. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.995 |
| Cul4a | Dcaf1 | ENSRNOP00000026653 | ENSRNOP00000075456 | RGD1563853 protein; Belongs to the cullin family. | DDB1 and CUL4-associated factor 1. | 0.999 |
| Cul4a | Dcaf11 | ENSRNOP00000026653 | ENSRNOP00000074435 | RGD1563853 protein; Belongs to the cullin family. | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.984 |
| Cul4a | Dda1 | ENSRNOP00000026653 | ENSRNOP00000057149 | RGD1563853 protein; Belongs to the cullin family. | DET1 and DDB1-associated 1. | 0.975 |
| Cul4a | Ddb1 | ENSRNOP00000026653 | ENSRNOP00000028188 | RGD1563853 protein; Belongs to the cullin family. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.999 |
| Cul4a | Ddb2 | ENSRNOP00000026653 | ENSRNOP00000018998 | RGD1563853 protein; Belongs to the cullin family. | Damage-specific DNA-binding protein 2. | 0.995 |
| Cul4a | Dtl | ENSRNOP00000026653 | ENSRNOP00000005576 | RGD1563853 protein; Belongs to the cullin family. | Denticleless E3 ubiquitin protein ligase homolog. | 0.982 |
| Cul4a | Ercc8 | ENSRNOP00000026653 | ENSRNOP00000013598 | RGD1563853 protein; Belongs to the cullin family. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.983 |
| Cul4a | Rbx1 | ENSRNOP00000026653 | ENSRNOP00000069049 | RGD1563853 protein; Belongs to the cullin family. | Ring-box 1. | 0.999 |