Sost protein (Rattus norvegicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bglap	LOC100912050	ENSRNOP00000026530	ENSRNOP00000015771	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	0.647
Bglap	LOC103689974	ENSRNOP00000026530	ENSRNOP00000013210	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...]	0.904
Bglap	Lrp5	ENSRNOP00000026530	ENSRNOP00000022213	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.572
Bglap	Lrp6	ENSRNOP00000026530	ENSRNOP00000071445	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.437
Bglap	Pth	ENSRNOP00000026530	ENSRNOP00000019199	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity); Belongs to the parathyroid hormone family.	0.915
Bglap	Sost	ENSRNOP00000026530	ENSRNOP00000028238	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; Belongs to the sclerostin family.	0.830
Bglap	Tnfrsf11b	ENSRNOP00000026530	ENSRNOP00000011344	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).	0.894
Bglap	Tnfsf11	ENSRNOP00000026530	ENSRNOP00000044212	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	TNF superfamily member 11.	0.855
Bglap	Wnt2	ENSRNOP00000026530	ENSRNOP00000071025	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.701
LOC100912050	Bglap	ENSRNOP00000015771	ENSRNOP00000026530	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.647
LOC100912050	LOC103689974	ENSRNOP00000015771	ENSRNOP00000013210	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...]	0.712
LOC100912050	Lrp5	ENSRNOP00000015771	ENSRNOP00000022213	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.994
LOC100912050	Lrp6	ENSRNOP00000015771	ENSRNOP00000071445	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.994
LOC100912050	Pth	ENSRNOP00000015771	ENSRNOP00000019199	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity); Belongs to the parathyroid hormone family.	0.598
LOC100912050	Sost	ENSRNOP00000015771	ENSRNOP00000028238	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; Belongs to the sclerostin family.	0.840
LOC100912050	Tnfrsf11b	ENSRNOP00000015771	ENSRNOP00000011344	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).	0.659
LOC100912050	Tnfsf11	ENSRNOP00000015771	ENSRNOP00000044212	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	TNF superfamily member 11.	0.694
LOC100912050	Wnt2	ENSRNOP00000015771	ENSRNOP00000071025	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.978
LOC103689974	Bglap	ENSRNOP00000013210	ENSRNOP00000026530	Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...]	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.904
LOC103689974	LOC100912050	ENSRNOP00000013210	ENSRNOP00000015771	Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...]	Dickkopf homolog 1 (Xenopus laevis) (Predicted).	0.712

page 1 of 5

Server load: low (18%) [HD]

Share

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About