node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aph1a | Aph1b | ENSRNOP00000073820 | ENSRNOP00000024207 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Anterior pharynx defective 1 homolog B (C. elegans). | 0.932 |
Aph1a | App | ENSRNOP00000073820 | ENSRNOP00000041613 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.833 |
Aph1a | Ncstn | ENSRNOP00000073820 | ENSRNOP00000008150 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. | 0.999 |
Aph1a | Notch1 | ENSRNOP00000073820 | ENSRNOP00000026212 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] | 0.920 |
Aph1a | Psen1 | ENSRNOP00000073820 | ENSRNOP00000012495 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.999 |
Aph1a | Psen2 | ENSRNOP00000073820 | ENSRNOP00000070964 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.999 |
Aph1a | Psenen | ENSRNOP00000073820 | ENSRNOP00000028438 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.999 |
Aph1a | Tmed10 | ENSRNOP00000073820 | ENSRNOP00000010512 | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.910 |
Aph1b | Aph1a | ENSRNOP00000024207 | ENSRNOP00000073820 | Anterior pharynx defective 1 homolog B (C. elegans). | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | 0.932 |
Aph1b | App | ENSRNOP00000024207 | ENSRNOP00000041613 | Anterior pharynx defective 1 homolog B (C. elegans). | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.734 |
Aph1b | Gsap | ENSRNOP00000024207 | ENSRNOP00000070072 | Anterior pharynx defective 1 homolog B (C. elegans). | Gamma-secretase-activating protein. | 0.518 |
Aph1b | Ncstn | ENSRNOP00000024207 | ENSRNOP00000008150 | Anterior pharynx defective 1 homolog B (C. elegans). | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. | 0.999 |
Aph1b | Notch1 | ENSRNOP00000024207 | ENSRNOP00000026212 | Anterior pharynx defective 1 homolog B (C. elegans). | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] | 0.864 |
Aph1b | Psen1 | ENSRNOP00000024207 | ENSRNOP00000012495 | Anterior pharynx defective 1 homolog B (C. elegans). | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.999 |
Aph1b | Psen2 | ENSRNOP00000024207 | ENSRNOP00000070964 | Anterior pharynx defective 1 homolog B (C. elegans). | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.999 |
Aph1b | Psenen | ENSRNOP00000024207 | ENSRNOP00000028438 | Anterior pharynx defective 1 homolog B (C. elegans). | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.999 |
Aph1b | Tmed10 | ENSRNOP00000024207 | ENSRNOP00000010512 | Anterior pharynx defective 1 homolog B (C. elegans). | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.892 |
App | Aph1a | ENSRNOP00000041613 | ENSRNOP00000073820 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a. | 0.833 |
App | Aph1b | ENSRNOP00000041613 | ENSRNOP00000024207 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Anterior pharynx defective 1 homolog B (C. elegans). | 0.734 |
App | Gsap | ENSRNOP00000041613 | ENSRNOP00000070072 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Gamma-secretase-activating protein. | 0.749 |