node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd13a | Gpha2 | ENSRNOP00000001595 | ENSRNOP00000028536 | Ankyrin repeat domain 13a. | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | 0.468 |
Ankrd13a | RGD1311899 | ENSRNOP00000001595 | ENSRNOP00000050415 | Ankyrin repeat domain 13a. | Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development; Belongs to the CUSTOS family. | 0.468 |
Cga | Gpha2 | ENSRNOP00000012385 | ENSRNOP00000028536 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | 0.842 |
Cga | Gphb5 | ENSRNOP00000012385 | ENSRNOP00000033047 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Glycoprotein hormone subunit beta 5. | 0.775 |
Cga | Tshb | ENSRNOP00000012385 | ENSRNOP00000022575 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.999 |
Cga | Tshr | ENSRNOP00000012385 | ENSRNOP00000005671 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Plays a central role in controlling thyroid cell metabolism. | 0.985 |
Git2 | Gpha2 | ENSRNOP00000048331 | ENSRNOP00000028536 | G protein-coupled receptor kinase interacting ArfGAP 2. | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | 0.632 |
Gpha2 | Ankrd13a | ENSRNOP00000028536 | ENSRNOP00000001595 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Ankyrin repeat domain 13a. | 0.468 |
Gpha2 | Cga | ENSRNOP00000028536 | ENSRNOP00000012385 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | 0.842 |
Gpha2 | Git2 | ENSRNOP00000028536 | ENSRNOP00000048331 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | G protein-coupled receptor kinase interacting ArfGAP 2. | 0.632 |
Gpha2 | Gphb5 | ENSRNOP00000028536 | ENSRNOP00000033047 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Glycoprotein hormone subunit beta 5. | 0.995 |
Gpha2 | Gpr1 | ENSRNOP00000028536 | ENSRNOP00000067327 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.955 |
Gpha2 | Mmab | ENSRNOP00000028536 | ENSRNOP00000066021 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.425 |
Gpha2 | RGD1311899 | ENSRNOP00000028536 | ENSRNOP00000050415 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development; Belongs to the CUSTOS family. | 0.468 |
Gpha2 | Rgs2 | ENSRNOP00000028536 | ENSRNOP00000005156 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] | 0.470 |
Gpha2 | Tshb | ENSRNOP00000028536 | ENSRNOP00000022575 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.747 |
Gpha2 | Tshr | ENSRNOP00000028536 | ENSRNOP00000005671 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Plays a central role in controlling thyroid cell metabolism. | 0.669 |
Gphb5 | Cga | ENSRNOP00000033047 | ENSRNOP00000012385 | Glycoprotein hormone subunit beta 5. | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | 0.775 |
Gphb5 | Gpha2 | ENSRNOP00000033047 | ENSRNOP00000028536 | Glycoprotein hormone subunit beta 5. | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | 0.995 |
Gphb5 | Tshb | ENSRNOP00000033047 | ENSRNOP00000022575 | Glycoprotein hormone subunit beta 5. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.591 |