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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpr137G protein-coupled receptor 137. (396 aa)    
Predicted Functional Partners:
Gpr158
Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family.
   
  
 0.670
Gprc5c
G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways.
      
 0.582
Gpr155
G protein-coupled receptor 155 (Predicted), isoform CRA_a.
      
 0.569
Tm7sf3
Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells (By similarity). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (By similarity).
   
  
 0.552
Trmt112
Similar to RIKEN cDNA 0610038D11 (Predicted), isoform CRA_b.
      
 0.546
Gpr152
G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family.
      
 0.545
Gpr82
G protein-coupled receptor 82.
      
 0.523
Gpr108
Protein GPR108.
   
  
 0.521
Rnf227
Similar to RIKEN cDNA A030009H04.
   
  
 0.501
Kcnk4
Potassium channel subfamily K member 4; Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane, and by raising the intracellular pH to basic levels. The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius. Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure ( [...]
   
  
 0.501
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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