node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcl3 | Chuk | ENSRNOP00000025913 | ENSRNOP00000034134 | BCL3, transcription coactivator. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.610 |
Bcl3 | Ikbkb | ENSRNOP00000025913 | ENSRNOP00000025851 | BCL3, transcription coactivator. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.644 |
Bcl3 | Nfkb1 | ENSRNOP00000025913 | ENSRNOP00000028944 | BCL3, transcription coactivator. | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | 0.993 |
Bcl3 | Nfkb2 | ENSRNOP00000025913 | ENSRNOP00000026235 | BCL3, transcription coactivator. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.980 |
Bcl3 | Nfkbia | ENSRNOP00000025913 | ENSRNOP00000009894 | BCL3, transcription coactivator. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). | 0.870 |
Bcl3 | Nfkbib | ENSRNOP00000025913 | ENSRNOP00000027212 | BCL3, transcription coactivator. | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.896 |
Bcl3 | Rel | ENSRNOP00000025913 | ENSRNOP00000072332 | BCL3, transcription coactivator. | REL proto-oncogene, NF-kB subunit. | 0.822 |
Bcl3 | Rela | ENSRNOP00000025913 | ENSRNOP00000044552 | BCL3, transcription coactivator. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.802 |
Bcl3 | Relb | ENSRNOP00000025913 | ENSRNOP00000054614 | BCL3, transcription coactivator. | RELB proto-oncogene, NF-kB subunit. | 0.848 |
Chuk | Bcl3 | ENSRNOP00000034134 | ENSRNOP00000025913 | Component of inhibitor of nuclear factor kappa B kinase complex. | BCL3, transcription coactivator. | 0.610 |
Chuk | Ikbkb | ENSRNOP00000034134 | ENSRNOP00000025851 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.999 |
Chuk | Map3k8 | ENSRNOP00000034134 | ENSRNOP00000022190 | Component of inhibitor of nuclear factor kappa B kinase complex. | Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a [...] | 0.917 |
Chuk | Nfkb1 | ENSRNOP00000034134 | ENSRNOP00000028944 | Component of inhibitor of nuclear factor kappa B kinase complex. | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | 0.995 |
Chuk | Nfkb2 | ENSRNOP00000034134 | ENSRNOP00000026235 | Component of inhibitor of nuclear factor kappa B kinase complex. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.984 |
Chuk | Nfkbia | ENSRNOP00000034134 | ENSRNOP00000009894 | Component of inhibitor of nuclear factor kappa B kinase complex. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). | 0.998 |
Chuk | Nfkbib | ENSRNOP00000034134 | ENSRNOP00000027212 | Component of inhibitor of nuclear factor kappa B kinase complex. | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.987 |
Chuk | Rel | ENSRNOP00000034134 | ENSRNOP00000072332 | Component of inhibitor of nuclear factor kappa B kinase complex. | REL proto-oncogene, NF-kB subunit. | 0.818 |
Chuk | Rela | ENSRNOP00000034134 | ENSRNOP00000044552 | Component of inhibitor of nuclear factor kappa B kinase complex. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.992 |
Chuk | Relb | ENSRNOP00000034134 | ENSRNOP00000054614 | Component of inhibitor of nuclear factor kappa B kinase complex. | RELB proto-oncogene, NF-kB subunit. | 0.908 |
Ikbkb | Bcl3 | ENSRNOP00000025851 | ENSRNOP00000025913 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | BCL3, transcription coactivator. | 0.644 |