Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
Fndc1Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling. (1831 aa)    
Predicted Functional Partners:
Appl2
DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interactio [...]
    
 0.788
Appl1
Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1.
    
 0.788
Plekha7
Pleckstrin homology domain-containing A7.
      
 0.573
Ankub1
Ankrin repeat and ubiquitin domain containing 1.
      
 0.571
Ankrd66
Ankyrin repeat domain 66.
    
 
 0.559
Lrrc71
Leucine-rich repeat-containing 71.
      
 0.554
RGD1564463
Similar to Mdes protein.
      
 0.551
Fam216b
Family with sequence similarity 216, member B.
      
 0.510
Tmem181
Transmembrane protein 181.
      
 0.508
Rsph3
Radial spoke head 3.
      
 0.499
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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