node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmp2 | Bmp4 | ENSRNOP00000028904 | ENSRNOP00000012957 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.946 |
Bmp2 | Bmp5 | ENSRNOP00000028904 | ENSRNOP00000014846 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Bone morphogenetic protein 5. | 0.448 |
Bmp2 | Bmp6 | ENSRNOP00000028904 | ENSRNOP00000018359 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Bone morphogenetic protein 6; Induces cartilage and bone formation. | 0.946 |
Bmp2 | Bmp7 | ENSRNOP00000028904 | ENSRNOP00000070891 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Bone morphogenetic protein 7. | 0.906 |
Bmp2 | Gdf5 | ENSRNOP00000028904 | ENSRNOP00000066703 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Growth differentiation factor 5. | 0.749 |
Bmp2 | Nog | ENSRNOP00000028904 | ENSRNOP00000030212 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | Noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). | 0.998 |
Bmp4 | Bmp2 | ENSRNOP00000012957 | ENSRNOP00000028904 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | 0.946 |
Bmp4 | Bmp5 | ENSRNOP00000012957 | ENSRNOP00000014846 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 5. | 0.454 |
Bmp4 | Bmp6 | ENSRNOP00000012957 | ENSRNOP00000018359 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 6; Induces cartilage and bone formation. | 0.967 |
Bmp4 | Bmp7 | ENSRNOP00000012957 | ENSRNOP00000070891 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 7. | 0.939 |
Bmp4 | Gdf5 | ENSRNOP00000012957 | ENSRNOP00000066703 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Growth differentiation factor 5. | 0.562 |
Bmp4 | Nog | ENSRNOP00000012957 | ENSRNOP00000030212 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). | 0.997 |
Bmp5 | Bmp2 | ENSRNOP00000014846 | ENSRNOP00000028904 | Bone morphogenetic protein 5. | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | 0.448 |
Bmp5 | Bmp4 | ENSRNOP00000014846 | ENSRNOP00000012957 | Bone morphogenetic protein 5. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.454 |
Bmp5 | Gdf7 | ENSRNOP00000014846 | ENSRNOP00000007928 | Bone morphogenetic protein 5. | Growth differentiation factor 7. | 0.424 |
Bmp5 | Nog | ENSRNOP00000014846 | ENSRNOP00000030212 | Bone morphogenetic protein 5. | Noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). | 0.982 |
Bmp6 | Bmp2 | ENSRNOP00000018359 | ENSRNOP00000028904 | Bone morphogenetic protein 6; Induces cartilage and bone formation. | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family. | 0.946 |
Bmp6 | Bmp4 | ENSRNOP00000018359 | ENSRNOP00000012957 | Bone morphogenetic protein 6; Induces cartilage and bone formation. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.967 |
Bmp6 | Gdf7 | ENSRNOP00000018359 | ENSRNOP00000007928 | Bone morphogenetic protein 6; Induces cartilage and bone formation. | Growth differentiation factor 7. | 0.467 |
Bmp6 | Nog | ENSRNOP00000018359 | ENSRNOP00000030212 | Bone morphogenetic protein 6; Induces cartilage and bone formation. | Noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). | 0.989 |