node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D4A7L5_RAT | Pias1 | ENSRNOP00000047101 | ENSRNOP00000059152 | Small ubiquitin-related modifier. | Protein inhibitor of activated STAT 1 (Predicted). | 0.889 |
D4A7L5_RAT | Pias3 | ENSRNOP00000047101 | ENSRNOP00000028814 | Small ubiquitin-related modifier. | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | 0.846 |
D4A7L5_RAT | Rangap1 | ENSRNOP00000047101 | ENSRNOP00000050029 | Small ubiquitin-related modifier. | RAN GTPase-activating protein 1. | 0.922 |
D4A7L5_RAT | Sae1 | ENSRNOP00000047101 | ENSRNOP00000020402 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.941 |
D4A7L5_RAT | Senp1 | ENSRNOP00000047101 | ENSRNOP00000031127 | Small ubiquitin-related modifier. | SUMO-specific peptidase 1. | 0.910 |
D4A7L5_RAT | Sumo1 | ENSRNOP00000047101 | ENSRNOP00000022048 | Small ubiquitin-related modifier. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.438 |
D4A7L5_RAT | Uba2 | ENSRNOP00000047101 | ENSRNOP00000028672 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.914 |
Pias1 | D4A7L5_RAT | ENSRNOP00000059152 | ENSRNOP00000047101 | Protein inhibitor of activated STAT 1 (Predicted). | Small ubiquitin-related modifier. | 0.889 |
Pias1 | Pias3 | ENSRNOP00000059152 | ENSRNOP00000028814 | Protein inhibitor of activated STAT 1 (Predicted). | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | 0.477 |
Pias1 | Rangap1 | ENSRNOP00000059152 | ENSRNOP00000050029 | Protein inhibitor of activated STAT 1 (Predicted). | RAN GTPase-activating protein 1. | 0.481 |
Pias1 | Sae1 | ENSRNOP00000059152 | ENSRNOP00000020402 | Protein inhibitor of activated STAT 1 (Predicted). | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.797 |
Pias1 | Senp1 | ENSRNOP00000059152 | ENSRNOP00000031127 | Protein inhibitor of activated STAT 1 (Predicted). | SUMO-specific peptidase 1. | 0.738 |
Pias1 | Sumo1 | ENSRNOP00000059152 | ENSRNOP00000022048 | Protein inhibitor of activated STAT 1 (Predicted). | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.983 |
Pias1 | Sumo2 | ENSRNOP00000059152 | ENSRNOP00000004867 | Protein inhibitor of activated STAT 1 (Predicted). | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.881 |
Pias1 | Sumo3 | ENSRNOP00000059152 | ENSRNOP00000001637 | Protein inhibitor of activated STAT 1 (Predicted). | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.891 |
Pias1 | Sumo4 | ENSRNOP00000059152 | ENSRNOP00000044856 | Protein inhibitor of activated STAT 1 (Predicted). | Small ubiquitin-related modifier. | 0.890 |
Pias1 | Uba2 | ENSRNOP00000059152 | ENSRNOP00000028672 | Protein inhibitor of activated STAT 1 (Predicted). | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.758 |
Pias3 | D4A7L5_RAT | ENSRNOP00000028814 | ENSRNOP00000047101 | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | Small ubiquitin-related modifier. | 0.846 |
Pias3 | Pias1 | ENSRNOP00000028814 | ENSRNOP00000059152 | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | Protein inhibitor of activated STAT 1 (Predicted). | 0.477 |
Pias3 | Sae1 | ENSRNOP00000028814 | ENSRNOP00000020402 | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.714 |