node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Batf2 | Cxcl9 | ENSRNOP00000028527 | ENSRNOP00000003627 | Basic leucine zipper ATF-like transcription factor 2. | C-X-C motif chemokine. | 0.412 |
Batf2 | Gbp2 | ENSRNOP00000028527 | ENSRNOP00000061437 | Basic leucine zipper ATF-like transcription factor 2. | Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). | 0.406 |
Batf2 | Gbp5 | ENSRNOP00000028527 | ENSRNOP00000033376 | Basic leucine zipper ATF-like transcription factor 2. | Guanylate-binding protein 5. | 0.624 |
Batf2 | Ifit2 | ENSRNOP00000028527 | ENSRNOP00000051639 | Basic leucine zipper ATF-like transcription factor 2. | Interferon-induced protein with tetratricopeptide repeats 2. | 0.439 |
Batf2 | Irf1 | ENSRNOP00000028527 | ENSRNOP00000010968 | Basic leucine zipper ATF-like transcription factor 2. | Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | 0.446 |
Cxcl10 | Cxcl9 | ENSRNOP00000003649 | ENSRNOP00000003627 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | C-X-C motif chemokine. | 0.998 |
Cxcl10 | Gbp2 | ENSRNOP00000003649 | ENSRNOP00000061437 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). | 0.697 |
Cxcl10 | Gbp5 | ENSRNOP00000003649 | ENSRNOP00000033376 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Guanylate-binding protein 5. | 0.673 |
Cxcl10 | Ifit2 | ENSRNOP00000003649 | ENSRNOP00000051639 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon-induced protein with tetratricopeptide repeats 2. | 0.821 |
Cxcl10 | Irf1 | ENSRNOP00000003649 | ENSRNOP00000010968 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | 0.858 |
Cxcl10 | Mx1 | ENSRNOP00000003649 | ENSRNOP00000043001 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). | 0.804 |
Cxcl10 | Oasl2 | ENSRNOP00000003649 | ENSRNOP00000001600 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 2'-5'-oligoadenylate synthase-like protein 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent p [...] | 0.587 |
Cxcl10 | Stat1 | ENSRNOP00000003649 | ENSRNOP00000070183 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Signal transducer and activator of transcription. | 0.909 |
Cxcl9 | Batf2 | ENSRNOP00000003627 | ENSRNOP00000028527 | C-X-C motif chemokine. | Basic leucine zipper ATF-like transcription factor 2. | 0.412 |
Cxcl9 | Cxcl10 | ENSRNOP00000003627 | ENSRNOP00000003649 | C-X-C motif chemokine. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.998 |
Cxcl9 | Gbp2 | ENSRNOP00000003627 | ENSRNOP00000061437 | C-X-C motif chemokine. | Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). | 0.527 |
Cxcl9 | Gbp5 | ENSRNOP00000003627 | ENSRNOP00000033376 | C-X-C motif chemokine. | Guanylate-binding protein 5. | 0.575 |
Cxcl9 | Ifit2 | ENSRNOP00000003627 | ENSRNOP00000051639 | C-X-C motif chemokine. | Interferon-induced protein with tetratricopeptide repeats 2. | 0.508 |
Cxcl9 | Irf1 | ENSRNOP00000003627 | ENSRNOP00000010968 | C-X-C motif chemokine. | Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | 0.653 |
Cxcl9 | Mx1 | ENSRNOP00000003627 | ENSRNOP00000043001 | C-X-C motif chemokine. | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). | 0.562 |