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Mavs protein (Rattus norvegicus) - STRING interaction network
"Mavs" - Mitochondrial antiviral-signaling protein in Rattus norvegicus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MavsMitochondrial antiviral-signaling protein ; Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that prov [...] (507 aa)    
Predicted Functional Partners:
Ifih1
Interferon-induced helicase C domain-containing protein 1 (1027 aa)
     
  0.980
Tbk1
Serine/threonine-protein kinase TBK1 (729 aa)
     
  0.949
Ddx58
Probable ATP-dependent RNA helicase DDX58 (598 aa)
       
  0.940
Traf3
TNF receptor-associated factor 3 (567 aa)
       
  0.934
Nlrx1
NLR family member X1 ; Participates in antiviral signaling (973 aa)
       
  0.931
Tmem173
Transmembrane protein 173 (379 aa)
       
  0.913
Dhx58
Probable ATP-dependent RNA helicase DHX58 (678 aa)
     
 
  0.907
Traf6
TNF receptor-associated factor 6 ; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems [...] (530 aa)
       
  0.877
Ikbke
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (717 aa)
     
  0.873
Atg12
Ubiquitin-like protein ATG12 ; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direc [...] (141 aa)
       
  0.826
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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