STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mis18bp1MIS18-binding protein 1. (990 aa)    
Predicted Functional Partners:
Mis18a
Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
   
  0.823
Oip5
Opa-interacting protein 5.
   
 
  0.809
Ndc80
NDC80 kinetochore complex component.
   
  
 0.793
Cenpa
Similar to centromere protein A (Predicted), isoform CRA_b.
   
 0.785
Top2a
DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.
   
 
 0.782
Bub1
Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted).
  
 
 0.776
Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B.
   
 
 0.726
Aspm
Abnormal spindle microtubule assembly.
   
    0.718
Kif11
Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.685
Cenpe
Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
   0.683
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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