node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dclre1a | Ercc1 | ENSRNOP00000034952 | ENSRNOP00000024113 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.754 |
Dclre1a | Ercc4 | ENSRNOP00000034952 | ENSRNOP00000004563 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | ERCC4 domain-containing protein. | 0.705 |
Dclre1a | Fan1 | ENSRNOP00000034952 | ENSRNOP00000032711 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.785 |
Dclre1a | Fancd2 | ENSRNOP00000034952 | ENSRNOP00000073556 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | Fanconi anemia group D2 protein homolog; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-ce [...] | 0.792 |
Dclre1a | Fanci | ENSRNOP00000034952 | ENSRNOP00000043744 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | FA complementation group I. | 0.766 |
Dclre1a | Fancm | ENSRNOP00000034952 | ENSRNOP00000074177 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | FA complementation group M. | 0.842 |
Dclre1a | Mus81 | ENSRNOP00000034952 | ENSRNOP00000028015 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.797 |
Dclre1a | Slx1b | ENSRNOP00000034952 | ENSRNOP00000026231 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.779 |
Dclre1a | Slx4 | ENSRNOP00000034952 | ENSRNOP00000031220 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | SLX4 structure-specific endonuclease subunit. | 0.709 |
Dclre1a | Terf2 | ENSRNOP00000034952 | ENSRNOP00000027695 | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.772 |
Ercc1 | Dclre1a | ENSRNOP00000024113 | ENSRNOP00000034952 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | 0.754 |
Ercc1 | Ercc4 | ENSRNOP00000024113 | ENSRNOP00000004563 | ERCC excision repair 1, endonuclease non-catalytic subunit. | ERCC4 domain-containing protein. | 0.999 |
Ercc1 | Fan1 | ENSRNOP00000024113 | ENSRNOP00000032711 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.763 |
Ercc1 | Fancd2 | ENSRNOP00000024113 | ENSRNOP00000073556 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Fanconi anemia group D2 protein homolog; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-ce [...] | 0.930 |
Ercc1 | Fanci | ENSRNOP00000024113 | ENSRNOP00000043744 | ERCC excision repair 1, endonuclease non-catalytic subunit. | FA complementation group I. | 0.922 |
Ercc1 | Fancm | ENSRNOP00000024113 | ENSRNOP00000074177 | ERCC excision repair 1, endonuclease non-catalytic subunit. | FA complementation group M. | 0.994 |
Ercc1 | Mus81 | ENSRNOP00000024113 | ENSRNOP00000028015 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.957 |
Ercc1 | Slx1b | ENSRNOP00000024113 | ENSRNOP00000026231 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.943 |
Ercc1 | Slx4 | ENSRNOP00000024113 | ENSRNOP00000031220 | ERCC excision repair 1, endonuclease non-catalytic subunit. | SLX4 structure-specific endonuclease subunit. | 0.975 |
Ercc4 | Dclre1a | ENSRNOP00000004563 | ENSRNOP00000034952 | ERCC4 domain-containing protein. | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). | 0.705 |