| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cyp26a1 | Dgat1 | ENSRNOP00000022549 | ENSRNOP00000035110 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | 0.918 |
| Cyp26a1 | Dhrs3 | ENSRNOP00000022549 | ENSRNOP00000021155 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.965 |
| Cyp26a1 | Dhrs9 | ENSRNOP00000022549 | ENSRNOP00000069708 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.948 |
| Cyp26a1 | Lrat | ENSRNOP00000022549 | ENSRNOP00000035053 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodo [...] | 0.973 |
| Cyp26a1 | Rbp1 | ENSRNOP00000022549 | ENSRNOP00000018622 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol-binding protein 1; Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.663 |
| Cyp26a1 | Rdh10 | ENSRNOP00000022549 | ENSRNOP00000009096 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. | 0.971 |
| Cyp26a1 | Rdh11 | ENSRNOP00000022549 | ENSRNOP00000069383 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.936 |
| Cyp26a1 | Rdh12 | ENSRNOP00000022549 | ENSRNOP00000074812 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.929 |
| Cyp26a1 | Retsat | ENSRNOP00000022549 | ENSRNOP00000019571 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.916 |
| Dgat1 | Cyp26a1 | ENSRNOP00000035110 | ENSRNOP00000022549 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.918 |
| Dgat1 | Dhrs3 | ENSRNOP00000035110 | ENSRNOP00000021155 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.909 |
| Dgat1 | Dhrs9 | ENSRNOP00000035110 | ENSRNOP00000069708 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.914 |
| Dgat1 | Lrat | ENSRNOP00000035110 | ENSRNOP00000035053 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodo [...] | 0.968 |
| Dgat1 | Rdh10 | ENSRNOP00000035110 | ENSRNOP00000009096 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. | 0.931 |
| Dgat1 | Rdh11 | ENSRNOP00000035110 | ENSRNOP00000069383 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.925 |
| Dgat1 | Rdh12 | ENSRNOP00000035110 | ENSRNOP00000074812 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.913 |
| Dgat1 | Retsat | ENSRNOP00000035110 | ENSRNOP00000019571 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.904 |
| Dgat1 | Rpe65 | ENSRNOP00000035110 | ENSRNOP00000069757 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.904 |
| Dhrs3 | Cyp26a1 | ENSRNOP00000021155 | ENSRNOP00000022549 | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.965 |
| Dhrs3 | Dgat1 | ENSRNOP00000021155 | ENSRNOP00000035110 | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Belongs to the membrane-bound acyltransf [...] | 0.909 |
