node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agxt2 | Gclc | ENSRNOP00000024035 | ENSRNOP00000035540 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate--cysteine ligase catalytic subunit. | 0.912 |
Agxt2 | Gclm | ENSRNOP00000024035 | ENSRNOP00000018343 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate--cysteine ligase regulatory subunit. | 0.915 |
Anpep | Gclc | ENSRNOP00000069456 | ENSRNOP00000035540 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutamate--cysteine ligase catalytic subunit. | 0.942 |
Anpep | Gclm | ENSRNOP00000069456 | ENSRNOP00000018343 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutamate--cysteine ligase regulatory subunit. | 0.936 |
Anpep | Ggct | ENSRNOP00000069456 | ENSRNOP00000049903 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Gamma-glutamyl cyclotransferase. | 0.902 |
Anpep | Ggt5 | ENSRNOP00000069456 | ENSRNOP00000076289 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.937 |
Anpep | Ggt6 | ENSRNOP00000069456 | ENSRNOP00000039691 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates. | 0.951 |
Anpep | Ggt7 | ENSRNOP00000069456 | ENSRNOP00000025315 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.944 |
Anpep | Gss | ENSRNOP00000069456 | ENSRNOP00000025657 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. | 0.935 |
Gclc | Agxt2 | ENSRNOP00000035540 | ENSRNOP00000024035 | Glutamate--cysteine ligase catalytic subunit. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.912 |
Gclc | Anpep | ENSRNOP00000035540 | ENSRNOP00000069456 | Glutamate--cysteine ligase catalytic subunit. | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | 0.942 |
Gclc | Gclm | ENSRNOP00000035540 | ENSRNOP00000018343 | Glutamate--cysteine ligase catalytic subunit. | Glutamate--cysteine ligase regulatory subunit. | 0.999 |
Gclc | Ggct | ENSRNOP00000035540 | ENSRNOP00000049903 | Glutamate--cysteine ligase catalytic subunit. | Gamma-glutamyl cyclotransferase. | 0.920 |
Gclc | Ggt5 | ENSRNOP00000035540 | ENSRNOP00000076289 | Glutamate--cysteine ligase catalytic subunit. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.924 |
Gclc | Ggt6 | ENSRNOP00000035540 | ENSRNOP00000039691 | Glutamate--cysteine ligase catalytic subunit. | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates. | 0.948 |
Gclc | Ggt7 | ENSRNOP00000035540 | ENSRNOP00000025315 | Glutamate--cysteine ligase catalytic subunit. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.931 |
Gclc | Gss | ENSRNOP00000035540 | ENSRNOP00000025657 | Glutamate--cysteine ligase catalytic subunit. | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. | 0.996 |
Gclc | Nqo1 | ENSRNOP00000035540 | ENSRNOP00000017175 | Glutamate--cysteine ligase catalytic subunit. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis; Belongs to the NAD(P)H dehydrogenase (quinone) family. | 0.925 |
Gclc | Oplah | ENSRNOP00000035540 | ENSRNOP00000074523 | Glutamate--cysteine ligase catalytic subunit. | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate; Belongs to the oxoprolinase family. | 0.955 |
Gclm | Agxt2 | ENSRNOP00000018343 | ENSRNOP00000024035 | Glutamate--cysteine ligase regulatory subunit. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.915 |