STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sit1Signaling threshold-regulating transmembrane adapter 1; Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells. (178 aa)    
Predicted Functional Partners:
Cd7
CD7 antigen (Predicted).
   
  
 0.736
Ly6d
Lymphocyte antigen 6 complex, locus D (Predicted).
   
  
 0.645
Themis
Thymocyte selection-associated.
   
  
 0.644
RT1-T24-4
Histocompatibility 2, T region locus 24; Belongs to the MHC class I family.
   
  
 0.584
Arl10
ADP-ribosylation factor-like 10, isoform CRA_a.
      
 0.495
Dsc1
Desmocollin 1.
      
 0.474
Slamf9
SLAM family member 9 (Predicted).
  
    0.439
Tmco2
Transmembrane and coiled-coil domains 2.
  
     0.409
F3
Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
      
 0.406
Psmd1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
      
 0.404
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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