Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
Cela3bElastase 3B, pancreatic (Predicted), isoform CRA_b; Belongs to the peptidase S1 family. (269 aa)    
Predicted Functional Partners:
Cpa1
Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
   
 
 0.999
Cela2a
Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.
  
0.996
Ctrc
Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity.
  
0.986
Cpb1
Carboxypeptidase B.
   
 
 0.984
Cel
Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285.
   
 0.981
Ctrl
Chymotrypsin-like, isoform CRA_a; Belongs to the peptidase S1 family.
  
  
0.967
Ctrb1
Chymotrypsin B chain A; Belongs to the peptidase S1 family.
  
  
0.957
Cpa2
Carboxypeptidase A2.
   
 
 0.939
Pnlip
Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
   
 
 0.921
Prss3
Cationic trypsin-3.
  
  
0.917
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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