node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccr1 | Ccr5 | ENSRNOP00000008772 | ENSRNOP00000073121 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.971 |
Ccr1 | Ccr6 | ENSRNOP00000008772 | ENSRNOP00000017302 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.598 |
Ccr1 | Ccr7 | ENSRNOP00000008772 | ENSRNOP00000014163 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.809 |
Ccr1 | Cx3cr1 | ENSRNOP00000008772 | ENSRNOP00000025019 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. | 0.534 |
Ccr1 | Cxcl16 | ENSRNOP00000008772 | ENSRNOP00000037160 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.851 |
Ccr1 | Cxcr1 | ENSRNOP00000008772 | ENSRNOP00000070273 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). | 0.751 |
Ccr1 | Cxcr2 | ENSRNOP00000008772 | ENSRNOP00000019109 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.608 |
Ccr1 | Cxcr3 | ENSRNOP00000008772 | ENSRNOP00000004406 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.829 |
Ccr1 | Cxcr4 | ENSRNOP00000008772 | ENSRNOP00000005143 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.818 |
Ccr1 | Cxcr6 | ENSRNOP00000008772 | ENSRNOP00000008294 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.516 |
Ccr5 | Ccr1 | ENSRNOP00000073121 | ENSRNOP00000008772 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.971 |
Ccr5 | Ccr6 | ENSRNOP00000073121 | ENSRNOP00000017302 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.518 |
Ccr5 | Ccr7 | ENSRNOP00000073121 | ENSRNOP00000014163 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.838 |
Ccr5 | Cx3cr1 | ENSRNOP00000073121 | ENSRNOP00000025019 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. | 0.576 |
Ccr5 | Cxcl16 | ENSRNOP00000073121 | ENSRNOP00000037160 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.940 |
Ccr5 | Cxcr1 | ENSRNOP00000073121 | ENSRNOP00000070273 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). | 0.593 |
Ccr5 | Cxcr2 | ENSRNOP00000073121 | ENSRNOP00000019109 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.708 |
Ccr5 | Cxcr3 | ENSRNOP00000073121 | ENSRNOP00000004406 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.803 |
Ccr5 | Cxcr4 | ENSRNOP00000073121 | ENSRNOP00000005143 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.952 |
Ccr5 | Cxcr6 | ENSRNOP00000073121 | ENSRNOP00000008294 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.629 |