STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F1M153_RATANK_REP_REGION domain-containing protein. (293 aa)    
Predicted Functional Partners:
Cdkn2c
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), isoform CRA_a.
  
     0.530
Mtpn
Myotrophin; Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
  
     0.513
Nfkbia
NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity).
  
     0.505
Nfkbie
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon.
  
     0.481
Ankrd49
Ankyrin repeat domain 49.
  
     0.480
Ankrd46
Ankyrin repeat domain-containing protein 46.
  
     0.467
Ankrd22
Ankyrin repeat domain 22.
  
     0.465
Asb16
Similar to ankyrin repeat domain-containing SOCS box protein Asb-16 (Predicted).
  
     0.441
Ppp1r27
Similar to protein phosphatase 1, regulatory subunit 12C; myosin-binding subunit 85 (Predicted).
  
     0.431
Tryx5
Trypsin X5; Belongs to the peptidase S1 family.
   
  
 0.427
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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