| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cntf | Ctf2 | ENSRNOP00000016690 | ENSRNOP00000046279 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Cardiotrophin 2. | 0.960 |
| Cntf | D3ZIP0_RAT | ENSRNOP00000016690 | ENSRNOP00000037716 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Uncharacterized protein. | 0.905 |
| Cntf | Il11 | ENSRNOP00000016690 | ENSRNOP00000023489 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin-11; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. | 0.973 |
| Cntf | Il13 | ENSRNOP00000016690 | ENSRNOP00000010121 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.924 |
| Cntf | Il31ra | ENSRNOP00000016690 | ENSRNOP00000064338 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin 31 receptor A. | 0.891 |
| Cntf | Il4r | ENSRNOP00000016690 | ENSRNOP00000020994 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.884 |
| Cntf | Jak1 | ENSRNOP00000016690 | ENSRNOP00000061649 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Tyrosine-protein kinase. | 0.928 |
| Cntf | Osm | ENSRNOP00000016690 | ENSRNOP00000032548 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G- CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration; Belongs to the LIF/OSM family. | 0.975 |
| Cntf | Osmr | ENSRNOP00000016690 | ENSRNOP00000039644 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM- specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.940 |
| Cntf | Tyk2 | ENSRNOP00000016690 | ENSRNOP00000048018 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Tyrosine-protein kinase. | 0.956 |
| Ctf2 | Cntf | ENSRNOP00000046279 | ENSRNOP00000016690 | Cardiotrophin 2. | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | 0.960 |
| Ctf2 | D3ZIP0_RAT | ENSRNOP00000046279 | ENSRNOP00000037716 | Cardiotrophin 2. | Uncharacterized protein. | 0.913 |
| Ctf2 | Il11 | ENSRNOP00000046279 | ENSRNOP00000023489 | Cardiotrophin 2. | Interleukin-11; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. | 0.960 |
| Ctf2 | Il13 | ENSRNOP00000046279 | ENSRNOP00000010121 | Cardiotrophin 2. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.884 |
| Ctf2 | Il31ra | ENSRNOP00000046279 | ENSRNOP00000064338 | Cardiotrophin 2. | Interleukin 31 receptor A. | 0.909 |
| Ctf2 | Il4r | ENSRNOP00000046279 | ENSRNOP00000020994 | Cardiotrophin 2. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.884 |
| Ctf2 | Jak1 | ENSRNOP00000046279 | ENSRNOP00000061649 | Cardiotrophin 2. | Tyrosine-protein kinase. | 0.905 |
| Ctf2 | Osm | ENSRNOP00000046279 | ENSRNOP00000032548 | Cardiotrophin 2. | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G- CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration; Belongs to the LIF/OSM family. | 0.963 |
| Ctf2 | Osmr | ENSRNOP00000046279 | ENSRNOP00000039644 | Cardiotrophin 2. | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM- specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.929 |
| Ctf2 | Tyk2 | ENSRNOP00000046279 | ENSRNOP00000048018 | Cardiotrophin 2. | Tyrosine-protein kinase. | 0.902 |
