| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Adipoq | Gpr1 | ENSRNOP00000002492 | ENSRNOP00000067327 | Adiponectin, C1Q and collagen domain-containing. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.415 |
| Adipoq | Rarres2 | ENSRNOP00000002492 | ENSRNOP00000038525 | Adiponectin, C1Q and collagen domain-containing. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.533 |
| Arrb1 | Gpr1 | ENSRNOP00000046069 | ENSRNOP00000067327 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.815 |
| Arrb1 | Rarres2 | ENSRNOP00000046069 | ENSRNOP00000038525 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.558 |
| Ccrl2 | Cmklr1 | ENSRNOP00000044084 | ENSRNOP00000000893 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). | 0.404 |
| Ccrl2 | Gpr1 | ENSRNOP00000044084 | ENSRNOP00000067327 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.851 |
| Ccrl2 | Rarres2 | ENSRNOP00000044084 | ENSRNOP00000038525 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.612 |
| Cmklr1 | Ccrl2 | ENSRNOP00000000893 | ENSRNOP00000044084 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | 0.404 |
| Cmklr1 | Rarres2 | ENSRNOP00000000893 | ENSRNOP00000038525 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.726 |
| Creb3l1 | Diras2 | ENSRNOP00000007771 | ENSRNOP00000041046 | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...] | DIRAS family GTPase 2. | 0.577 |
| Creb3l1 | Lrrc17 | ENSRNOP00000007771 | ENSRNOP00000017103 | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...] | Leucine-rich repeat-containing 17. | 0.584 |
| Creb3l1 | Rarres2 | ENSRNOP00000007771 | ENSRNOP00000038525 | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...] | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.519 |
| Diras2 | Creb3l1 | ENSRNOP00000041046 | ENSRNOP00000007771 | DIRAS family GTPase 2. | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...] | 0.577 |
| Diras2 | Lrrc17 | ENSRNOP00000041046 | ENSRNOP00000017103 | DIRAS family GTPase 2. | Leucine-rich repeat-containing 17. | 0.611 |
| Diras2 | Rarres2 | ENSRNOP00000041046 | ENSRNOP00000038525 | DIRAS family GTPase 2. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.584 |
| Gpr1 | Adipoq | ENSRNOP00000067327 | ENSRNOP00000002492 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Adiponectin, C1Q and collagen domain-containing. | 0.415 |
| Gpr1 | Arrb1 | ENSRNOP00000067327 | ENSRNOP00000046069 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.815 |
| Gpr1 | Ccrl2 | ENSRNOP00000067327 | ENSRNOP00000044084 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | 0.851 |
| Gpr1 | Rarres2 | ENSRNOP00000067327 | ENSRNOP00000038525 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.887 |
| Gpr50 | Rarres2 | ENSRNOP00000015147 | ENSRNOP00000038525 | Melatonin-related receptor; Does not bind melatonin. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.557 |
