node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdh5 | Pard3b | ENSRNOP00000017983 | ENSRNOP00000039831 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Par-3 family cell polarity regulator beta. | 0.563 |
Cdh5 | Pard6a | ENSRNOP00000017983 | ENSRNOP00000069044 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. | 0.501 |
Iqch | Pard3b | ENSRNOP00000073182 | ENSRNOP00000039831 | IQ motif-containing H. | Par-3 family cell polarity regulator beta. | 0.572 |
Llgl1 | Pard3b | ENSRNOP00000005366 | ENSRNOP00000039831 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Par-3 family cell polarity regulator beta. | 0.574 |
Llgl1 | Pard6a | ENSRNOP00000005366 | ENSRNOP00000069044 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. | 0.826 |
Llgl1 | Pard6b | ENSRNOP00000005366 | ENSRNOP00000014568 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Par-6 (Partitioning defective 6) homolog beta (C. elegans) (Predicted). | 0.747 |
Llgl1 | Pard6g | ENSRNOP00000005366 | ENSRNOP00000073302 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Par-6 family cell polarity regulator gamma. | 0.743 |
Llgl1 | Prkci | ENSRNOP00000005366 | ENSRNOP00000012924 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] | 0.977 |
Llgl1 | Prkcz | ENSRNOP00000005366 | ENSRNOP00000021285 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] | 0.978 |
Lypd5 | Pard3b | ENSRNOP00000026288 | ENSRNOP00000039831 | Ly6/Plaur domain-containing 5. | Par-3 family cell polarity regulator beta. | 0.571 |
Pard3b | Cdh5 | ENSRNOP00000039831 | ENSRNOP00000017983 | Par-3 family cell polarity regulator beta. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.563 |
Pard3b | Iqch | ENSRNOP00000039831 | ENSRNOP00000073182 | Par-3 family cell polarity regulator beta. | IQ motif-containing H. | 0.572 |
Pard3b | Llgl1 | ENSRNOP00000039831 | ENSRNOP00000005366 | Par-3 family cell polarity regulator beta. | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. | 0.574 |
Pard3b | Lypd5 | ENSRNOP00000039831 | ENSRNOP00000026288 | Par-3 family cell polarity regulator beta. | Ly6/Plaur domain-containing 5. | 0.571 |
Pard3b | Pard6a | ENSRNOP00000039831 | ENSRNOP00000069044 | Par-3 family cell polarity regulator beta. | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. | 0.654 |
Pard3b | Pard6b | ENSRNOP00000039831 | ENSRNOP00000014568 | Par-3 family cell polarity regulator beta. | Par-6 (Partitioning defective 6) homolog beta (C. elegans) (Predicted). | 0.654 |
Pard3b | Pard6g | ENSRNOP00000039831 | ENSRNOP00000073302 | Par-3 family cell polarity regulator beta. | Par-6 family cell polarity regulator gamma. | 0.654 |
Pard3b | Plch1 | ENSRNOP00000039831 | ENSRNOP00000068291 | Par-3 family cell polarity regulator beta. | Phosphoinositide phospholipase C. | 0.538 |
Pard3b | Prkci | ENSRNOP00000039831 | ENSRNOP00000012924 | Par-3 family cell polarity regulator beta. | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] | 0.789 |
Pard3b | Prkcz | ENSRNOP00000039831 | ENSRNOP00000021285 | Par-3 family cell polarity regulator beta. | Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] | 0.789 |