STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Serpina11Serpin A11; Belongs to the serpin family. (462 aa)    
Predicted Functional Partners:
Lrrc66
Leucine-rich repeat-containing protein 66.
      
 0.612
Fgl1
Fibrinogen-like protein 1; Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
   
  
 0.595
C8a
Complement component 8, alpha polypeptide (Predicted).
   
  
 0.556
Tyw3
tRNA-yW synthesizing protein 3 homolog.
      
 0.545
Lrrc27
Leucine-rich repeat-containing 27.
      
 0.538
LOC103689975
Integrator complex subunit 1-like.
      
 0.535
Itih3
Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family.
   
  
 0.517
Tpcn2
Two pore segment channel 2 (Predicted), isoform CRA_a.
   
  
 0.512
Eif2b3
Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP.
   
  
 0.511
Itih1
Inter-alpha trypsin inhibitor, heavy chain 1 (Predicted), isoform CRA_a.
   
  
 0.511
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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