node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fgf14 | Fgfr1 | ENSRNOP00000042838 | ENSRNOP00000043459 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.711 |
Fgf14 | Fgfr2 | ENSRNOP00000042838 | ENSRNOP00000059005 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Fibroblast growth factor receptor. | 0.623 |
Fgf14 | Fgfr4 | ENSRNOP00000042838 | ENSRNOP00000069871 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | 0.637 |
Fgf14 | Gpr158 | ENSRNOP00000042838 | ENSRNOP00000038884 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.617 |
Fgf14 | Mapk8ip2 | ENSRNOP00000042838 | ENSRNOP00000052648 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. | 0.721 |
Fgf14 | Scn2a | ENSRNOP00000042838 | ENSRNOP00000007069 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Sodium channel protein type 2 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). | 0.800 |
Fgf14 | Scn3a | ENSRNOP00000042838 | ENSRNOP00000006646 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium- selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (By similarity). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). Belo [...] | 0.656 |
Fgf14 | Scn5a | ENSRNOP00000042838 | ENSRNOP00000060180 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Sodium channel protein type 5 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. | 0.703 |
Fgf14 | Scn8a | ENSRNOP00000042838 | ENSRNOP00000008160 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.795 |
Fgf14 | Scn9a | ENSRNOP00000042838 | ENSRNOP00000059170 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin- sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain. | 0.686 |
Fgfr1 | Fgf14 | ENSRNOP00000043459 | ENSRNOP00000042838 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Fibroblast growth factor 14; Probably involved in nervous system development and function. | 0.711 |
Fgfr1 | Fgfr2 | ENSRNOP00000043459 | ENSRNOP00000059005 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Fibroblast growth factor receptor. | 0.717 |
Fgfr1 | Fgfr4 | ENSRNOP00000043459 | ENSRNOP00000069871 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | 0.899 |
Fgfr2 | Fgf14 | ENSRNOP00000059005 | ENSRNOP00000042838 | Fibroblast growth factor receptor. | Fibroblast growth factor 14; Probably involved in nervous system development and function. | 0.623 |
Fgfr2 | Fgfr1 | ENSRNOP00000059005 | ENSRNOP00000043459 | Fibroblast growth factor receptor. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.717 |
Fgfr2 | Fgfr4 | ENSRNOP00000059005 | ENSRNOP00000069871 | Fibroblast growth factor receptor. | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | 0.929 |
Fgfr4 | Fgf14 | ENSRNOP00000069871 | ENSRNOP00000042838 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | Fibroblast growth factor 14; Probably involved in nervous system development and function. | 0.637 |
Fgfr4 | Fgfr1 | ENSRNOP00000069871 | ENSRNOP00000043459 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.899 |
Fgfr4 | Fgfr2 | ENSRNOP00000069871 | ENSRNOP00000059005 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | Fibroblast growth factor receptor. | 0.929 |
Gpr158 | Fgf14 | ENSRNOP00000038884 | ENSRNOP00000042838 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Fibroblast growth factor 14; Probably involved in nervous system development and function. | 0.617 |