node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eif2ak2 | Ifit1 | ENSRNOP00000071646 | ENSRNOP00000025770 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced protein with tetratricopeptide repeats 1. | 0.981 |
Eif2ak2 | Ifit3 | ENSRNOP00000071646 | ENSRNOP00000033267 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced protein with tetratricopeptide repeats 3. | 0.654 |
Eif2ak2 | Irf7 | ENSRNOP00000071646 | ENSRNOP00000023504 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon regulatory factor 7. | 0.851 |
Eif2ak2 | Irf9 | ENSRNOP00000071646 | ENSRNOP00000026364 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon regulatory factor 9. | 0.731 |
Eif2ak2 | Isg15 | ENSRNOP00000071646 | ENSRNOP00000035405 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.987 |
Eif2ak2 | Mx1 | ENSRNOP00000071646 | ENSRNOP00000043001 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). | 0.858 |
Eif2ak2 | Mx2 | ENSRNOP00000071646 | ENSRNOP00000002695 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.822 |
Eif2ak2 | Oas1a | ENSRNOP00000071646 | ENSRNOP00000036734 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | 2'-5'-oligoadenylate synthase 1A; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] | 0.811 |
Eif2ak2 | Rsad2 | ENSRNOP00000071646 | ENSRNOP00000010092 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.927 |
Eif2ak2 | Usp18 | ENSRNOP00000071646 | ENSRNOP00000053020 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. | 0.854 |
Ifit1 | Eif2ak2 | ENSRNOP00000025770 | ENSRNOP00000071646 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | 0.981 |
Ifit1 | Ifit3 | ENSRNOP00000025770 | ENSRNOP00000033267 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon-induced protein with tetratricopeptide repeats 3. | 0.874 |
Ifit1 | Irf7 | ENSRNOP00000025770 | ENSRNOP00000023504 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon regulatory factor 7. | 0.937 |
Ifit1 | Irf9 | ENSRNOP00000025770 | ENSRNOP00000026364 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon regulatory factor 9. | 0.810 |
Ifit1 | Isg15 | ENSRNOP00000025770 | ENSRNOP00000035405 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.943 |
Ifit1 | Mx1 | ENSRNOP00000025770 | ENSRNOP00000043001 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). | 0.832 |
Ifit1 | Mx2 | ENSRNOP00000025770 | ENSRNOP00000002695 | Interferon-induced protein with tetratricopeptide repeats 1. | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.804 |
Ifit1 | Oas1a | ENSRNOP00000025770 | ENSRNOP00000036734 | Interferon-induced protein with tetratricopeptide repeats 1. | 2'-5'-oligoadenylate synthase 1A; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] | 0.813 |
Ifit1 | Rsad2 | ENSRNOP00000025770 | ENSRNOP00000010092 | Interferon-induced protein with tetratricopeptide repeats 1. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.951 |
Ifit1 | Usp18 | ENSRNOP00000025770 | ENSRNOP00000053020 | Interferon-induced protein with tetratricopeptide repeats 1. | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. | 0.959 |