node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
En1 | Lmx1a | ENSRNOP00000068605 | ENSRNOP00000006163 | Homeobox protein engrailed-like. | LIM homeobox transcription factor 1 alpha. | 0.453 |
En1 | Lmx1b | ENSRNOP00000068605 | ENSRNOP00000022953 | Homeobox protein engrailed-like. | LIM homeobox transcription factor 1 beta. | 0.436 |
En1 | Nr4a2 | ENSRNOP00000068605 | ENSRNOP00000043812 | Homeobox protein engrailed-like. | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver- specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR. | 0.730 |
En1 | Pitx3 | ENSRNOP00000068605 | ENSRNOP00000026013 | Homeobox protein engrailed-like. | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] | 0.481 |
En1 | Slc18a2 | ENSRNOP00000068605 | ENSRNOP00000011983 | Homeobox protein engrailed-like. | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.601 |
En1 | Th | ENSRNOP00000068605 | ENSRNOP00000027682 | Homeobox protein engrailed-like. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.592 |
Fosb | Nr4a2 | ENSRNOP00000065427 | ENSRNOP00000043812 | FosB proto-oncogene, AP-1 transcription factor subunit. | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver- specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR. | 0.780 |
Fosb | Nr4a3 | ENSRNOP00000065427 | ENSRNOP00000008302 | FosB proto-oncogene, AP-1 transcription factor subunit. | Nuclear receptor subfamily 4 group A member 3; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth musc [...] | 0.713 |
Fosb | Th | ENSRNOP00000065427 | ENSRNOP00000027682 | FosB proto-oncogene, AP-1 transcription factor subunit. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.522 |
Lmx1a | En1 | ENSRNOP00000006163 | ENSRNOP00000068605 | LIM homeobox transcription factor 1 alpha. | Homeobox protein engrailed-like. | 0.453 |
Lmx1a | Lmx1b | ENSRNOP00000006163 | ENSRNOP00000022953 | LIM homeobox transcription factor 1 alpha. | LIM homeobox transcription factor 1 beta. | 0.402 |
Lmx1a | Nr4a2 | ENSRNOP00000006163 | ENSRNOP00000043812 | LIM homeobox transcription factor 1 alpha. | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver- specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR. | 0.834 |
Lmx1a | Pitx3 | ENSRNOP00000006163 | ENSRNOP00000026013 | LIM homeobox transcription factor 1 alpha. | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] | 0.450 |
Lmx1a | Slc18a2 | ENSRNOP00000006163 | ENSRNOP00000011983 | LIM homeobox transcription factor 1 alpha. | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.655 |
Lmx1a | Th | ENSRNOP00000006163 | ENSRNOP00000027682 | LIM homeobox transcription factor 1 alpha. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.695 |
Lmx1b | En1 | ENSRNOP00000022953 | ENSRNOP00000068605 | LIM homeobox transcription factor 1 beta. | Homeobox protein engrailed-like. | 0.436 |
Lmx1b | Lmx1a | ENSRNOP00000022953 | ENSRNOP00000006163 | LIM homeobox transcription factor 1 beta. | LIM homeobox transcription factor 1 alpha. | 0.402 |
Lmx1b | Nr4a2 | ENSRNOP00000022953 | ENSRNOP00000043812 | LIM homeobox transcription factor 1 beta. | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver- specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR. | 0.748 |
Lmx1b | Pitx3 | ENSRNOP00000022953 | ENSRNOP00000026013 | LIM homeobox transcription factor 1 beta. | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] | 0.453 |
Lmx1b | Slc18a2 | ENSRNOP00000022953 | ENSRNOP00000011983 | LIM homeobox transcription factor 1 beta. | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.641 |