Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
Lca5Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. (727 aa)    
Predicted Functional Partners:
Aipl1
Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization.
      
 0.724
Trappc5
Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
   
 
 0.705
Rdh12
Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.701
Cep290
Centrosomal protein 290.
   
 
 0.700
Spata7
Spermatogenesis-associated protein 7 homolog; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). Required for photoreceptor- specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor- specific extension of the primary cilium transition zone (By similarity). Maintenance of protein localization at the photoreceptor- specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity).
      
 0.686
Trappc4
Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
   
 
 0.678
Trappc1
Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
   
 
 0.664
Trappc2l
Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
   
 
 0.663
Gucy2e
Retinal guanylyl cyclase 1; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.
   
  
 0.659
Trappc8
Trafficking protein particle complex 8.
    
 
 0.656
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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