Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slc39a4Zinc transporter ZIP4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity); Belongs to the ZIP transporter (TC 2.A.5) family. (657 aa)    
Predicted Functional Partners:
Slc39a3
Zinc transporter ZIP3; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family.
   
 0.963
Slc39a1
Solute carrier family 39 member 1.
   
 0.941
Slc39a2
Solute carrier family 39 (Zinc transporter), member 2 (Predicted), isoform CRA_a.
   
 0.913
Slc11a2
Natural resistance-associated macrophage protein 2; May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Belongs to the NRAMP family.
  
 
 0.910
Slc39a9
Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family.
    
 0.907
Slc39a7
Solute carrier family 39 (Zinc transporter), member 7.
  
  
0.906
Slc39a6
Zinc transporter ZIP6; May act as a zinc-influx transporter.
  
  
0.895
Slc39a10
Solute carrier family 39 (Zinc transporter), member 10 (Predicted), isoform CRA_a.
   
 
0.882
Slc39a11
Zinc transporter ZIP11; Functions as a cellular zinc transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
   
 0.841
Slc39a12
Solute carrier family 39 member 12.
  
  
0.828
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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