node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asip | Defb14 | ENSRNOP00000023905 | ENSRNOP00000048330 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.650 |
Ccr6 | Defb1 | ENSRNOP00000017302 | ENSRNOP00000018428 | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.558 |
Ccr6 | Defb14 | ENSRNOP00000017302 | ENSRNOP00000048330 | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.582 |
Ccr6 | Defb4 | ENSRNOP00000017302 | ENSRNOP00000054838 | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | Beta-defensin 4; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells. | 0.588 |
Ccr6 | Tlr1 | ENSRNOP00000017302 | ENSRNOP00000055898 | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | Toll-like receptor. | 0.489 |
Defb1 | Ccr6 | ENSRNOP00000018428 | ENSRNOP00000017302 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.558 |
Defb1 | Defb10 | ENSRNOP00000018428 | ENSRNOP00000054867 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 10; Has antibacterial activity; Belongs to the beta-defensin family. | 0.465 |
Defb1 | Defb14 | ENSRNOP00000018428 | ENSRNOP00000048330 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.955 |
Defb1 | Defb3 | ENSRNOP00000018428 | ENSRNOP00000018655 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 5; Has antibacterial activity; Belongs to the beta-defensin family. | 0.758 |
Defb1 | Defb30 | ENSRNOP00000018428 | ENSRNOP00000055981 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 30; Has antibacterial activity; Belongs to the beta-defensin family. | 0.633 |
Defb1 | Defb4 | ENSRNOP00000018428 | ENSRNOP00000054838 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 4; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells. | 0.992 |
Defb10 | Defb1 | ENSRNOP00000054867 | ENSRNOP00000018428 | Beta-defensin 10; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.465 |
Defb10 | Defb14 | ENSRNOP00000054867 | ENSRNOP00000048330 | Beta-defensin 10; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.561 |
Defb10 | Defb4 | ENSRNOP00000054867 | ENSRNOP00000054838 | Beta-defensin 10; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 4; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells. | 0.422 |
Defb14 | Asip | ENSRNOP00000048330 | ENSRNOP00000023905 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). | 0.650 |
Defb14 | Ccr6 | ENSRNOP00000048330 | ENSRNOP00000017302 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.582 |
Defb14 | Defb1 | ENSRNOP00000048330 | ENSRNOP00000018428 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.955 |
Defb14 | Defb10 | ENSRNOP00000048330 | ENSRNOP00000054867 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 10; Has antibacterial activity; Belongs to the beta-defensin family. | 0.561 |
Defb14 | Defb3 | ENSRNOP00000048330 | ENSRNOP00000018655 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 5; Has antibacterial activity; Belongs to the beta-defensin family. | 0.588 |
Defb14 | Defb30 | ENSRNOP00000048330 | ENSRNOP00000055981 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 30; Has antibacterial activity; Belongs to the beta-defensin family. | 0.670 |