node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd74 | Ctsa | ENSRNOP00000025354 | ENSRNOP00000062425 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.470 |
Cd74 | Ctsb | ENSRNOP00000025354 | ENSRNOP00000014178 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.717 |
Cd74 | Ctsc | ENSRNOP00000025354 | ENSRNOP00000022342 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity). | 0.683 |
Cd74 | Ctse | ENSRNOP00000025354 | ENSRNOP00000048353 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity). | 0.548 |
Cd74 | Ctsf | ENSRNOP00000025354 | ENSRNOP00000026718 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin F, isoform CRA_a; Belongs to the peptidase C1 family. | 0.527 |
Cd74 | Ctsh | ENSRNOP00000025354 | ENSRNOP00000074611 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | 0.650 |
Cd74 | Ctsl | ENSRNOP00000025354 | ENSRNOP00000025462 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | 0.699 |
Cd74 | Ctss | ENSRNOP00000025354 | ENSRNOP00000028732 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). May be involved in thyroid hormone biosynthesis. Belongs to the peptidase C1 family. | 0.824 |
Cd74 | RT1-Db1 | ENSRNOP00000025354 | ENSRNOP00000000522 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Rano class II histocompatibility antigen, D-1 beta chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class II family. | 0.999 |
Ctsa | Cd74 | ENSRNOP00000062425 | ENSRNOP00000025354 | Carboxypeptidase; Belongs to the peptidase S10 family. | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | 0.470 |
Ctsa | Ctsb | ENSRNOP00000062425 | ENSRNOP00000014178 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.796 |
Ctsa | Ctsc | ENSRNOP00000062425 | ENSRNOP00000022342 | Carboxypeptidase; Belongs to the peptidase S10 family. | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity). | 0.631 |
Ctsa | Ctse | ENSRNOP00000062425 | ENSRNOP00000048353 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity). | 0.494 |
Ctsa | Ctsf | ENSRNOP00000062425 | ENSRNOP00000026718 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin F, isoform CRA_a; Belongs to the peptidase C1 family. | 0.567 |
Ctsa | Ctsh | ENSRNOP00000062425 | ENSRNOP00000074611 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | 0.606 |
Ctsa | Ctsl | ENSRNOP00000062425 | ENSRNOP00000025462 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | 0.542 |
Ctsa | Ctss | ENSRNOP00000062425 | ENSRNOP00000028732 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). May be involved in thyroid hormone biosynthesis. Belongs to the peptidase C1 family. | 0.697 |
Ctsa | Ctsz | ENSRNOP00000062425 | ENSRNOP00000066523 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides ; Belongs to the peptidase C1 family. | 0.627 |
Ctsa | RT1-Db1 | ENSRNOP00000062425 | ENSRNOP00000000522 | Carboxypeptidase; Belongs to the peptidase S10 family. | Rano class II histocompatibility antigen, D-1 beta chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class II family. | 0.425 |
Ctsb | Cd74 | ENSRNOP00000014178 | ENSRNOP00000025354 | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | 0.717 |