node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cop1 | Cul4a | ENSRNOP00000048511 | ENSRNOP00000026653 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | RGD1563853 protein; Belongs to the cullin family. | 0.935 |
Cop1 | Cul4b | ENSRNOP00000048511 | ENSRNOP00000060639 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.855 |
Cop1 | Dda1 | ENSRNOP00000048511 | ENSRNOP00000057149 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | DET1 and DDB1-associated 1. | 0.790 |
Cop1 | Ddb1 | ENSRNOP00000048511 | ENSRNOP00000028188 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.956 |
Cop1 | Ddb2 | ENSRNOP00000048511 | ENSRNOP00000018998 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Damage-specific DNA-binding protein 2. | 0.942 |
Cop1 | Det1 | ENSRNOP00000048511 | ENSRNOP00000058942 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | DET1 partner of COP1 E3 ubiquitin ligase. | 0.987 |
Cop1 | Ercc8 | ENSRNOP00000048511 | ENSRNOP00000013598 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.902 |
Cop1 | Rbx1 | ENSRNOP00000048511 | ENSRNOP00000069049 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Ring-box 1. | 0.903 |
Cop1 | Tp53 | ENSRNOP00000048511 | ENSRNOP00000074031 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.891 |
Cop1 | Trib3 | ENSRNOP00000048511 | ENSRNOP00000009840 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activi [...] | 0.854 |
Cul4a | Cop1 | ENSRNOP00000026653 | ENSRNOP00000048511 | RGD1563853 protein; Belongs to the cullin family. | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | 0.935 |
Cul4a | Cul4b | ENSRNOP00000026653 | ENSRNOP00000060639 | RGD1563853 protein; Belongs to the cullin family. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.995 |
Cul4a | Dda1 | ENSRNOP00000026653 | ENSRNOP00000057149 | RGD1563853 protein; Belongs to the cullin family. | DET1 and DDB1-associated 1. | 0.975 |
Cul4a | Ddb1 | ENSRNOP00000026653 | ENSRNOP00000028188 | RGD1563853 protein; Belongs to the cullin family. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.999 |
Cul4a | Ddb2 | ENSRNOP00000026653 | ENSRNOP00000018998 | RGD1563853 protein; Belongs to the cullin family. | Damage-specific DNA-binding protein 2. | 0.995 |
Cul4a | Det1 | ENSRNOP00000026653 | ENSRNOP00000058942 | RGD1563853 protein; Belongs to the cullin family. | DET1 partner of COP1 E3 ubiquitin ligase. | 0.974 |
Cul4a | Ercc8 | ENSRNOP00000026653 | ENSRNOP00000013598 | RGD1563853 protein; Belongs to the cullin family. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.983 |
Cul4a | Rbx1 | ENSRNOP00000026653 | ENSRNOP00000069049 | RGD1563853 protein; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul4a | Tp53 | ENSRNOP00000026653 | ENSRNOP00000074031 | RGD1563853 protein; Belongs to the cullin family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.672 |
Cul4b | Cop1 | ENSRNOP00000060639 | ENSRNOP00000048511 | Cullin 4B (Predicted); Belongs to the cullin family. | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | 0.855 |