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Fndc5 protein (Rattus norvegicus) - STRING interaction network
"Fndc5" - Fibronectin type III domain-containing protein 5 Irisin in Rattus norvegicus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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[Homology]
Score
Fndc5Fibronectin type III domain-containing protein 5 Irisin; Irisin- mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity) (209 aa)    
Predicted Functional Partners:
Cpsf3l
Integrator complex subunit 11 ; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3’ cleavage (By similarity) (600 aa)
           
  0.557
Zmpste24
CAAX prenyl protease 1 homolog (475 aa)
           
  0.557
Ypel4
Protein yippee-like 4 (127 aa)
           
  0.557
Amt
Aminomethyltransferase, mitochondrial (403 aa)
           
  0.556
Egln3
Egl nine homolog 3 ; Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both [...] (355 aa)
           
  0.556
C1ql3
Complement C1q-like protein 3 precursor (255 aa)
           
  0.486
C1ql2
Complement C1q-like protein 2 precursor (287 aa)
           
  0.483
Ucp1
Mitochondrial brown fat uncoupling protein 1 ; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (307 aa)
           
  0.482
Ypel1
RCG36512; Uncharacterized protein (118 aa)
           
  0.476
Pex14
Peroxisomal membrane protein PEX14 ; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin (376 aa)
           
  0.430
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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