node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adipoq | Bdnf | ENSRNOP00000002492 | ENSRNOP00000064356 | Adiponectin, C1Q and collagen domain-containing. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.450 |
Adipoq | Fgf21 | ENSRNOP00000002492 | ENSRNOP00000028490 | Adiponectin, C1Q and collagen domain-containing. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.790 |
Adipoq | Fndc5 | ENSRNOP00000002492 | ENSRNOP00000048830 | Adiponectin, C1Q and collagen domain-containing. | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity). | 0.660 |
Adipoq | Mstn | ENSRNOP00000002492 | ENSRNOP00000038159 | Adiponectin, C1Q and collagen domain-containing. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | 0.496 |
Adipoq | Ppargc1a | ENSRNOP00000002492 | ENSRNOP00000006071 | Adiponectin, C1Q and collagen domain-containing. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.811 |
Adipoq | Prdm16 | ENSRNOP00000002492 | ENSRNOP00000064955 | Adiponectin, C1Q and collagen domain-containing. | PR/SET domain 16. | 0.660 |
Adipoq | Ucp1 | ENSRNOP00000002492 | ENSRNOP00000004900 | Adiponectin, C1Q and collagen domain-containing. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...] | 0.844 |
Bdnf | Adipoq | ENSRNOP00000064356 | ENSRNOP00000002492 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Adiponectin, C1Q and collagen domain-containing. | 0.450 |
Bdnf | Fgf21 | ENSRNOP00000064356 | ENSRNOP00000028490 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.700 |
Bdnf | Fndc5 | ENSRNOP00000064356 | ENSRNOP00000048830 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity). | 0.691 |
Bdnf | Ppargc1a | ENSRNOP00000064356 | ENSRNOP00000006071 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.637 |
Bdnf | Ucp1 | ENSRNOP00000064356 | ENSRNOP00000004900 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...] | 0.403 |
Fgf21 | Adipoq | ENSRNOP00000028490 | ENSRNOP00000002492 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Adiponectin, C1Q and collagen domain-containing. | 0.790 |
Fgf21 | Bdnf | ENSRNOP00000028490 | ENSRNOP00000064356 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.700 |
Fgf21 | Fndc5 | ENSRNOP00000028490 | ENSRNOP00000048830 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity). | 0.719 |
Fgf21 | Metrn | ENSRNOP00000028490 | ENSRNOP00000026676 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). | 0.499 |
Fgf21 | Mstn | ENSRNOP00000028490 | ENSRNOP00000038159 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | 0.548 |
Fgf21 | Ostn | ENSRNOP00000028490 | ENSRNOP00000043654 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Processed Osteocrin; Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked [...] | 0.409 |
Fgf21 | Ppargc1a | ENSRNOP00000028490 | ENSRNOP00000006071 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.754 |
Fgf21 | Prdm16 | ENSRNOP00000028490 | ENSRNOP00000064955 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | PR/SET domain 16. | 0.620 |