Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Cpn2Carboxypeptidase N subunit 2. (565 aa)    
Predicted Functional Partners:
Cpn1
Carboxypeptidase N catalytic chain; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation; Belongs to the peptidase M14 family.
   
 0.953
Gp1ba
Glycoprotein Ib platelet subunit alpha.
  
0.805
Gp9
Glycoprotein IX (platelet).
   
 0.789
Sspo
SCO-spondin; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity); Belongs to the thrombospondin family.
    
 0.788
Gp1bb
Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
   
 0.744
A0A0G2JV94_RAT
Uncharacterized protein.
      
 0.741
LOC102549888
Uncharacterized protein.
      
 0.741
LOC365791
Similar to T-cell activation Rho GTPase-activating protein isoform b.
      
 0.741
LOC100361706
Ig lambda-1 chain C region.
      
 0.673
Vwf
Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).
    
 0.660
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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