| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Btbd9 | Map2k5 | ENSRNOP00000000649 | ENSRNOP00000050528 | BTB/POZ domain-containing protein 9. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | 0.792 |
| Btbd9 | Skor1 | ENSRNOP00000000649 | ENSRNOP00000018756 | BTB/POZ domain-containing protein 9. | SKI family transcriptional corepressor 1; Inhibits BMP signaling. Acts as a transcriptional corepressor of LBX1 (By similarity). | 0.790 |
| LOC100912585 | Map2k5 | ENSRNOP00000064205 | ENSRNOP00000050528 | Mitogen-activated protein kinase 7-like. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | 0.962 |
| LOC100912585 | Map3k4 | ENSRNOP00000064205 | ENSRNOP00000072741 | Mitogen-activated protein kinase 7-like. | Mitogen-activated protein kinase kinase kinase 4. | 0.437 |
| Map2k5 | Btbd9 | ENSRNOP00000050528 | ENSRNOP00000000649 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | BTB/POZ domain-containing protein 9. | 0.792 |
| Map2k5 | LOC100912585 | ENSRNOP00000050528 | ENSRNOP00000064205 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase 7-like. | 0.962 |
| Map2k5 | Map3k2 | ENSRNOP00000050528 | ENSRNOP00000057715 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase kinase kinase 2. | 0.989 |
| Map2k5 | Map3k3 | ENSRNOP00000050528 | ENSRNOP00000074780 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.991 |
| Map2k5 | Map3k4 | ENSRNOP00000050528 | ENSRNOP00000072741 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase kinase kinase 4. | 0.776 |
| Map2k5 | Mapk1 | ENSRNOP00000050528 | ENSRNOP00000002533 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.814 |
| Map2k5 | Mapk3 | ENSRNOP00000050528 | ENSRNOP00000070784 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.850 |
| Map2k5 | Mapk7 | ENSRNOP00000050528 | ENSRNOP00000054673 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ER [...] | 0.981 |
| Map2k5 | Skor1 | ENSRNOP00000050528 | ENSRNOP00000018756 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | SKI family transcriptional corepressor 1; Inhibits BMP signaling. Acts as a transcriptional corepressor of LBX1 (By similarity). | 0.810 |
| Map2k5 | Sqstm1 | ENSRNOP00000050528 | ENSRNOP00000056021 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery (By similarity). Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth f [...] | 0.795 |
| Map3k2 | Map2k5 | ENSRNOP00000057715 | ENSRNOP00000050528 | Mitogen-activated protein kinase kinase kinase 2. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | 0.989 |
| Map3k2 | Map3k3 | ENSRNOP00000057715 | ENSRNOP00000074780 | Mitogen-activated protein kinase kinase kinase 2. | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.951 |
| Map3k2 | Map3k4 | ENSRNOP00000057715 | ENSRNOP00000072741 | Mitogen-activated protein kinase kinase kinase 2. | Mitogen-activated protein kinase kinase kinase 4. | 0.911 |
| Map3k2 | Mapk7 | ENSRNOP00000057715 | ENSRNOP00000054673 | Mitogen-activated protein kinase kinase kinase 2. | Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ER [...] | 0.515 |
| Map3k3 | Map2k5 | ENSRNOP00000074780 | ENSRNOP00000050528 | Mitogen activated protein kinase kinase kinase 3 (Predicted). | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | 0.991 |
| Map3k3 | Map3k2 | ENSRNOP00000074780 | ENSRNOP00000057715 | Mitogen activated protein kinase kinase kinase 3 (Predicted). | Mitogen-activated protein kinase kinase kinase 2. | 0.951 |
